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  Cell-Type Specific Properties of Pyramidal Neurons in Neocortex Underlying a Layout that Is Modifiable Depending on the Cortical Area

Groh, A., Meyer, H. S., Schmidt, E. F., Heintz, N., Sakmann, B., & Krieger, P. (2010). Cell-Type Specific Properties of Pyramidal Neurons in Neocortex Underlying a Layout that Is Modifiable Depending on the Cortical Area. Cerebral Cortex, 20(4), 826-836.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-1FC5-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-1FC6-3
Genre: Journal Article

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 Creators:
Groh, A.1, Author
Meyer, H. S.1, Author
Schmidt, E. F.1, Author
Heintz, N.1, Author
Sakmann, B.2, Author              
Krieger, P.1, Author
Affiliations:
1[Krieger, Patrik] Karolinska Inst, Dept Neurosci, Nobel Inst Neurophysiol, SE-17177 Stockholm, Sweden.; [Meyer, Hanno S.] Max Planck Inst Med Res, D-69120 Heidelberg, Germany.; [Schmidt, Eric F.; Heintz, Nathaniel] Rockefeller Univ, Mol Biol Lab, New York, NY 10065 USA.; [Groh, Alexander; Sakmann, Bert] Tech Univ Munich, Inst Neurosci, D-80802 Munich, Germany., ou_persistent22              
2Emeritus Group: Cortical Column in silico / Sakmann, MPI of Neurobiology, Max Planck Society, ou_1113549              

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Free keywords: BAC transgenic; connectivity; dendrite morphology; neocortex; pyramidal cell
 Abstract: To understand sensory representation in cortex, it is crucial to identify its constituent cellular components based on cell-type-specific criteria. With the identification of cell types, an important question can be addressed: to what degree does the cellular properties of neurons depend on cortical location? We tested this question using pyramidal neurons in layer 5 (L5) because of their role in providing major cortical output to subcortical targets. Recently developed transgenic mice with cell-type-specific enhanced green fluorescent protein labeling of neuronal subtypes allow reliable identification of 2 cortical cell types in L5 throughout the entire neocortex. A comprehensive investigation of anatomical and functional properties of these 2 cell types in visual and somatosensory cortex demonstrates that, with important exceptions, most properties appear to be cell-type-specific rather than dependent on cortical area. This result suggests that although cortical output neurons share a basic layout throughout the sensory cortex, fine differences in properties are tuned to the cortical area in which neurons reside.

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Language(s): eng - English
 Dates: 2010-04
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 475440
ISI: 000275566500007
 Degree: -

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Title: Cerebral Cortex
  Alternative Title : Cereb. Cortex
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 20 (4) Sequence Number: - Start / End Page: 826 - 836 Identifier: ISSN: 1047-3211