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  Axon Extension Occurs Independently of Centrosomal Microtubule Nucleation

Stiess, M., Maghelli, N., Kapitein, L. C., Gomis-Rueth, S., Wilsch-Brauninger, M., Hoogenraad, C. C., et al. (2010). Axon Extension Occurs Independently of Centrosomal Microtubule Nucleation. Science, 327(5966), 704-707.

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 Creators:
Stiess, M.1, Author              
Maghelli, N.2, Author
Kapitein, L. C.2, Author
Gomis-Rueth, S.1, Author              
Wilsch-Brauninger, M.2, Author
Hoogenraad, C. C.2, Author
Tolic-Norrelykke, I. M.2, Author
Bradke, F.1, Author              
Affiliations:
1Max Planck Research Group: Axonal Growth and Regeneration / Bradke, MPI of Neurobiology, Max Planck Society, ou_1113553              
2[Maghelli, Nicola; Wilsch-Braeuninger, Michaela; Tolic-Norrelykke, Iva M.] Max Planck Inst Mol Cell Biol & Genet, D-01307 Dresden, Germany.; [Kapitein, Lukas C.; Hoogenraad, Casper C.] Erasmus MC, Dept Neurosci, NL-3015 GE Rotterdam, Netherlands., ou_persistent22              

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 Abstract: Microtubules are polymeric protein structures and components of the cytoskeleton. Their dynamic polymerization is important for diverse cellular functions. The centrosome is the classical site of microtubule nucleation and is thought to be essential for axon growth and neuronal differentiation-processes that require microtubule assembly. We found that the centrosome loses its function as a microtubule organizing center during development of rodent hippocampal neurons. Axons still extended and regenerated through acentrosomal microtubule nucleation, and axons continued to grow after laser ablation of the centrosome in early neuronal development. Thus, decentralized microtubule assembly enables axon extension and regeneration, and, after axon initiation, acentrosomal microtubule nucleation arranges the cytoskeleton, which is the source of the sophisticated morphology of neurons.

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Language(s): eng - English
 Dates: 2010-02-05
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 474428
ISI: 000274251800042
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Title: Science
  Alternative Title : Science
Source Genre: Journal
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Pages: - Volume / Issue: 327 (5966) Sequence Number: - Start / End Page: 704 - 707 Identifier: ISSN: 0036-8075