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  Identifying targets for autoantibodies in CNS inflammation: Strategies and achievements

Meinl, E., Derfuss, T., & Linington, C. (2010). Identifying targets for autoantibodies in CNS inflammation: Strategies and achievements. Clinical and Experimental Neuroimmunology, 1(2), 47-60.

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Meinl, E.1, Author              
Derfuss, T.1, Author              
Linington, C.1, Author              
Affiliations:
1Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society, ou_1113547              

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 Abstract: B cells and antibodies are increasingly recognized as an important feature in a broad variety of autoimmune and infectious central nervous system (CNS) diseases, such as multiple sclerosis, neuromyelitis optica, paraneoplastic diseases, acute demyelinating encephalomyelitis, Sydenham chorea, stiff-person syndrome and channelopathies. Autoantibodies might serve as a biomarker to identify the disease entity. Beyond this, autoantibodies can be a relevant pathogenic component. The present review focuses on strategies applied to identify the targets of autoantibodies and to test their pathogenetic relevance. The pathways of autoantibodies into and out of the CNS are summarized and the issue whether pathogenicity requires recognition of an extracellular target is discussed.

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Language(s): eng - English
 Dates: 2010
 Publication Status: Published in print
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 Rev. Type: -
 Identifiers: eDoc: 532974
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Title: Clinical and Experimental Neuroimmunology
Source Genre: Journal
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Pages: - Volume / Issue: 1 (2) Sequence Number: - Start / End Page: 47 - 60 Identifier: ISSN: 1759-1961