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  Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells

Pöllinger, B., Krishnamoorthy, G., Berer, K., Lassmann, H., Bösl, M. R., Dunn, R., et al. (2009). Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells. Journal of Experimental Medicine, 206(6), 1303-1316.

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 Creators:
Pöllinger, B.1, Author              
Krishnamoorthy, G.1, Author              
Berer, K.1, Author              
Lassmann, H.2, Author
Bösl, M. R.3, Author              
Dunn, R.2, Author
Domingues, H. S.1, Author              
Holz, A.1, Author              
Kurschus, F. C.1, Author              
Wekerle, H.1, Author              
Affiliations:
1Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society, ou_1113547              
2[Lassmann, Hans] Med Univ Vienna, Ctr Brain Res, A-1090 Vienna, Austria.; [Dunn, Robert] Biogen Idec, Dept Immunol, San Diego, CA 92122 USA., ou_persistent22              
3Department: Molecular Neurobiology / Klein, MPI of Neurobiology, Max Planck Society, ou_1113546              

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 Abstract: We describe new T cell receptor (TCR) transgenic mice (relapsing-remitting [RR] mice) carrying a TCR specific for myelin oligodendrocyte glycoprotein (MOG) peptide 92-106 in the context of I-A(s). Backcrossed to the SJL/J background, most RR mice spontaneously develop RR experimental autoimmune encephalomyelitis (EAE) with episodes often altering between different central nervous system tissues like the cerebellum, optic nerve, and spinal cord. Development of spontaneous EAE depends on the presence of an intact B cell compartment and on the expression of MOG autoantigen. There is no spontaneous EAE development in B cell-depleted mice or in transgenic mice lacking MOG. Transgenic T cells seem to expand MOG autoreactive B cells from the endogenous repertoire. The expanded autoreactive B cells produce autoantibodies binding to a conformational epitope on the native MOG protein while ignoring the T cell target peptide. The secreted autoantibodies are pathogenic, enhancing demyelinating EAE episodes. RR mice constitute the first spontaneous animal model for the most common form of multiple sclerosis (MS), RR MS.

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Language(s): eng - English
 Dates: 2009-06-08
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 433292
ISI: 000267133700010
 Degree: -

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Title: Journal of Experimental Medicine
  Alternative Title : J. Exp. Med.
Source Genre: Journal
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Pages: - Volume / Issue: 206 (6) Sequence Number: - Start / End Page: 1303 - 1316 Identifier: ISSN: 0022-1007