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  Cross-reactive T-Cell Receptors in Tumor and Paraneoplastic Target Tissue

Pellkofer, H. L., Voltz, R., Goebels, N., Hohlfeld, R., & Dornmair, K. (2009). Cross-reactive T-Cell Receptors in Tumor and Paraneoplastic Target Tissue. Archives of Neurology, 66(5), 655-658.

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Pellkofer et al Archives Neurol.pdf (Publisher version), 120KB
 
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Pellkofer, H. L.1, Author
Voltz, R.2, Author              
Goebels, N.2, Author              
Hohlfeld, R.2, Author              
Dornmair, K.2, Author              
Affiliations:
1[Pellkofer, Hannah L.; Hohlfeld, Reinhard; Dornmair, Klaus] Univ Munich, Univ Hosp Grosshadern, Inst Clin Neuroimmunol, Munich, Germany.; [Voltz, Raymond] Univ Cologne, Univ Hosp, Dept Palliat Med, Cologne, Germany.; [Goebels, Norbert] Univ Zurich Hosp, Neurol Klin, CH-8091 Zurich, Switzerland., ou_persistent22              
2Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society, ou_1113547              

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 Abstract: Background: According to established criteria, paraneoplastic encephalomyelitis with adrenal neuroblastoma comprises a definite paraneoplastic neurologic syndrome. Objective: To detect T-cell clones that cross-react against antigens shared between tumor and nervous system. Design: Case study. Setting: Academic research. Patient: A 22-year-old woman having paraneoplastic encephalomyelitis with adrenal neuroblastoma. Main Outcome Measures: We compared the T-cell receptor repertoires expressed in blood, cerebrospinal fluid, and neuroblastoma tumor tissue using complementary determining region 3 (CDR3) spectratyping and clone-specific polymerase chain reaction. Results: The T-cell receptor repertoire in cerebrospinal fluid was narrow compared with that in tumor and blood. Four T-cell clones from different tissues had identical T-cell receptor beta chains. Remarkably, the chains showed identical amino acid sequences but different nucleotide sequences. Conclusions: These T cells represent ontogenetically distinct clones but share functionally identical receptors. They recognize the same antigen in nervous system and tumor tissue and represent an attractive target for selective therapy.

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Language(s): eng - English
 Dates: 2009-05
 Publication Status: Published in print
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 Rev. Type: Peer
 Identifiers: eDoc: 432455
ISI: 000265993700015
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Title: Archives of Neurology
  Alternative Title : Arch. Neurol.
Source Genre: Journal
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Pages: - Volume / Issue: 66 (5) Sequence Number: - Start / End Page: 655 - 658 Identifier: ISSN: 0003-9942