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  Serine phosphorylation of ephrinB2 regulates trafficking of synaptic AMPA receptors

Essmann, C. L., Martinez, E., Geiger, J. C., Zimmer, M., Traut, M. H., Stein, V., et al. (2008). Serine phosphorylation of ephrinB2 regulates trafficking of synaptic AMPA receptors. Nature Neuroscience, 11(9), 1035-1043.

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 Creators:
Essmann, C. L.1, Author              
Martinez, E.1, Author              
Geiger, J. C.1, Author              
Zimmer, M.2, Author              
Traut, M. H.3, Author              
Stein, V.3, Author              
Klein, R.2, Author              
Acker-Palmer, A.1, Author              
Affiliations:
1Research Group: Signal Transduction / Acker-Palmer, MPI of Neurobiology, Max Planck Society, ou_1113563              
2Department: Molecular Neurobiology / Klein, MPI of Neurobiology, Max Planck Society, ou_1113546              
3Max Planck Research Group: Synaptic Receptor Trafficking / Stein, MPI of Neurobiology, Max Planck Society, ou_1113557              

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 Abstract: Plasticity in the brain is essential for maintaining memory and learning and is associated with the dynamic membrane trafficking of AMPA receptors. EphrinB proteins, ligands for EphB receptor tyrosine kinases, are transmembrane molecules with signaling capabilities that are required for spine morphogenesis, synapse formation and synaptic plasticity. Here, we describe a molecular mechanism for ephrinB2 function in controlling synaptic transmission. EphrinB2 signaling is critical for the stabilization of AMPA receptors at the cellular membrane. Mouse hippocampal neurons from conditional ephrinB2 knockouts showed enhanced constitutive internalization of AMPA receptors and reduced synaptic transmission. Mechanistically, glutamate receptor interacting proteins bridge ephrinB ligands and AMPA receptors. Moreover, this function involved a regulatory aspect of ephrinB reverse signaling that involves the phosphorylation of a single serine residue in their cytoplasmic tails. In summary, our findings uncover a model of cooperative AMPA receptor and ephrinB reverse signaling at the synapse.

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Language(s): eng - English
 Dates: 2008-09
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 412732
ISI: 000258720000013
 Degree: -

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Title: Nature Neuroscience
  Alternative Title : Nat. Neurosci.
Source Genre: Journal
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Pages: - Volume / Issue: 11 (9) Sequence Number: - Start / End Page: 1035 - 1043 Identifier: ISSN: 1097-6256