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  T-cell-mediated autoimmunity - Novel techniques to characterize autoreactive T-cell receptors

Dornmair, K., Goebels, N., Weltzien, H. U., Wekerle, H., & Hohlfeld, R. (2003). T-cell-mediated autoimmunity - Novel techniques to characterize autoreactive T-cell receptors. American Journal of Pathology, 163(4), 1215-1226.

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Dornmair, Klaus1, Author           
Goebels, Norbert1, Author           
Weltzien, H. U.2, Author
Wekerle, Hartmut1, Author           
Hohlfeld, Reinhard1, Author           
Affiliations:
1Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society, ou_1113547              
2Max Planck Inst Neurobiol, D-82152 Martinsried, Germany.; Univ Munich, Inst Clin Neuroimmunol, Munich, Germany.; Univ Munich, Klinkum Grosshadern, Munich, Germany.; Max Planck Inst Immunol, Freiberg, Germany., ou_persistent22              

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 Abstract: Histological samples of autopsy or biopsy tissue provide the best available evidence that autoreactive T cells are involved in the immunopathogenesis of many autoimmune diseases. However, morphology alone does not provide information on the antigen-specific T-cell receptor (TCR) of these cells, let alone on their antigen specificity. in this review article we discuss a number of emerging possibilities for identifying TCR sequences directly from biopsy tissue. We also review the methods for expressing presumably autoreactive TCR molecules and speculate on how the expressed TCR might be used to identify target antigens. Such information should eventually provide new insights into disease pathogenesis which lead to better therapies.

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Language(s): eng - English
 Dates: 2003-10
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 127483
ISI: 000185517500001
 Degree: -

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Title: American Journal of Pathology
  Alternative Title : Am. J. Pathol.
Source Genre: Journal
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Pages: - Volume / Issue: 163 (4) Sequence Number: - Start / End Page: 1215 - 1226 Identifier: ISSN: 0002-9440