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  Treatment with glatiramer acetate induces specific IgG4 antibodies in multiple sclerosis patients

Farina, C., Vargas-Leal, V., Heydari, N., Kümpfel, T., Meinl, E., & Hohlfeld, R. (2002). Treatment with glatiramer acetate induces specific IgG4 antibodies in multiple sclerosis patients. Journal of Neuroimmunology, 123(1-2), 188-192.

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 Creators:
Farina, Cinthia1, Author           
Vargas-Leal, Vivian1, Author           
Heydari, N.2, Author
Kümpfel, Tania1, Author           
Meinl, Edgar1, Author           
Hohlfeld, Reinhard1, Author           
Affiliations:
1Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society, ou_1113547              
2Max Planck Inst Neurobiol, Dept Neuroimmunol, Klopferspitz 18A,; D-82152 Martinsried, Germany; Max Planck Inst Neurobiol, Dept Neuroimmunol, D-82152 Martinsried, Germany; Univ Munich, Inst Clin Neuroimmunol, D-81366 Munich, Germany, ou_persistent22              

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Free keywords: multiple sclerosis; auto immunity; TH2-lymphocytes
 Abstract: We analysed the humoral immune response to glatiramer acetate (GA, Copaxone) in 20 multiple sclerosis patients treated with GA, 20 patients not treated with GA and 20 normal control subjects. Using an ELISA for detection of total GA-reactive immunoglobulins (all isotypes), all treated patients but also 3/20 untreated and 8/20 healthy subjects scored positive at 1:20 plasma dilutions. At higher dilutions, 5/20 treated patients and two healthy donors had relatively high levels of anti-GA antibodies. Isotype and IgG subclass analysis revealed that the two antibody-positive normal subjects had IgM and small titers of IgG1 or IgG2 antibodies. In contrast, 18 of 20 GA-treated patients, had low but significant titers of GA- reactive IgG4 antibodies. This finding is consistent with the previously described GA-mediated induction of T-helper 2 (TH2)- like regulatory T cells. (C) 2002 Elsevier Science B.V All rights reserved.

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Language(s): eng - English
 Dates: 2002-02
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 10798
ISI: 000174761200021
 Degree: -

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Title: Journal of Neuroimmunology
  Alternative Title : J. Neuroimmunol.
Source Genre: Journal
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Pages: - Volume / Issue: 123 (1-2) Sequence Number: - Start / End Page: 188 - 192 Identifier: ISSN: 0165-5728