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  Treatment with glatiramer acetate induces specific IgG4 antibodies in multiple sclerosis patients

Farina, C., Vargas-Leal, V., Heydari, N., Kümpfel, T., Meinl, E., & Hohlfeld, R. (2002). Treatment with glatiramer acetate induces specific IgG4 antibodies in multiple sclerosis patients. Journal of Neuroimmunology, 123(1-2), 188-192.

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Farina, Cinthia1, Autor           
Vargas-Leal, Vivian1, Autor           
Heydari, N.2, Autor
Kümpfel, Tania1, Autor           
Meinl, Edgar1, Autor           
Hohlfeld, Reinhard1, Autor           
Affiliations:
1Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society, ou_1113547              
2Max Planck Inst Neurobiol, Dept Neuroimmunol, Klopferspitz 18A,; D-82152 Martinsried, Germany; Max Planck Inst Neurobiol, Dept Neuroimmunol, D-82152 Martinsried, Germany; Univ Munich, Inst Clin Neuroimmunol, D-81366 Munich, Germany, ou_persistent22              

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Schlagwörter: multiple sclerosis; auto immunity; TH2-lymphocytes
 Zusammenfassung: We analysed the humoral immune response to glatiramer acetate (GA, Copaxone) in 20 multiple sclerosis patients treated with GA, 20 patients not treated with GA and 20 normal control subjects. Using an ELISA for detection of total GA-reactive immunoglobulins (all isotypes), all treated patients but also 3/20 untreated and 8/20 healthy subjects scored positive at 1:20 plasma dilutions. At higher dilutions, 5/20 treated patients and two healthy donors had relatively high levels of anti-GA antibodies. Isotype and IgG subclass analysis revealed that the two antibody-positive normal subjects had IgM and small titers of IgG1 or IgG2 antibodies. In contrast, 18 of 20 GA-treated patients, had low but significant titers of GA- reactive IgG4 antibodies. This finding is consistent with the previously described GA-mediated induction of T-helper 2 (TH2)- like regulatory T cells. (C) 2002 Elsevier Science B.V All rights reserved.

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Sprache(n): eng - English
 Datum: 2002-02
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 10798
ISI: 000174761200021
 Art des Abschluß: -

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Titel: Journal of Neuroimmunology
  Alternativer Titel : J. Neuroimmunol.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 123 (1-2) Artikelnummer: - Start- / Endseite: 188 - 192 Identifikator: ISSN: 0165-5728