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  Loss of sensory input causes rapid structural changes of inhibitory neurons in adult mouse visual cortex

Keck, T., Scheuss, V., Jacobsen, R. I., Wierenga, C. J., Eysel, U. T., Bonhoeffer, T., et al. (2011). Loss of sensory input causes rapid structural changes of inhibitory neurons in adult mouse visual cortex. Neuron, 71(5), 869-882. doi:10.1016/j.neuron.2011.06.034.

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 Creators:
Keck, Tara1, Author              
Scheuss, Volker1, Author              
Jacobsen, R. Irene1, Author              
Wierenga, Corette J.1, Author              
Eysel, Ulf T.2, Author
Bonhoeffer, Tobias1, Author              
Hübener, Mark1, Author              
Affiliations:
1Department: Cellular and Systems Neurobiology / Bonhoeffer, MPI of Neurobiology, Max Planck Society, ou_1113545              
2External Organizations, ou_persistent22              

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Free keywords: ACTIVITY-DEPENDENT REGULATION; CAT STRIATE CORTEX; LONG-TERM; FUNCTIONAL REORGANIZATION; HIPPOCAMPAL-NEURONS; IN-VIVO; RETINAL LESIONS; RAT HIPPOCAMPUS; SPINE GROWTH; AREA 17Neurosciences;
 Abstract: A fundamental property of neuronal circuits is the ability to adapt to altered sensory inputs. It is well established that the functional synaptic changes underlying this adaptation are reflected by structural modifications in excitatory neurons. In contrast, the degree to which structural plasticity in inhibitory neurons accompanies functional changes is less clear. Here, we use two-photon imaging to monitor the fine structure of inhibitory neurons in mouse visual cortex after deprivation induced by retinal lesions. We find that a subset of inhibitory neurons carry dendritic spines, which form glutamatergic synapses. Removal of visual input correlates with a rapid and lasting reduction in the number of inhibitory cell spines. Similar to the effects seen for dendritic spines, the number of inhibitory neuron boutons dropped sharply after retinal lesions. Together, these data suggest that structural changes in inhibitory neurons may precede structural changes in excitatory circuitry, which ultimately result in functional adaptation following sensory deprivation.

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Language(s): eng - English
 Dates: 2011
 Publication Status: Published in print
 Pages: 14
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Degree: -

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Title: Neuron
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 71 (5) Sequence Number: - Start / End Page: 869 - 882 Identifier: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565