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  Antibodies to MOG are transient in childhood acute disseminated encephalomyelitis

Pröbstel, A.-K., Dornmair, K., Bittner, R., Sperl, P., Jenne, D. E., Magalhaes, S., et al. (2011). Antibodies to MOG are transient in childhood acute disseminated encephalomyelitis. Neurology, 77(6), 580-588. doi:10.1212/WNL.0b013e318228c0b1.

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 Creators:
Pröbstel, Anne-Katrin1, Author              
Dornmair, Klaus1, Author              
Bittner, Robert1, Author              
Sperl, Petra1, Author              
Jenne, Dieter E.1, Author              
Magalhaes, S., Author
Villalobos, A., Author
Breithaupt, C., Author
Weissert, R., Author
Jacob, U., Author
Krumbholz, Markus1, Author              
Kuempfel, T., Author
Blaschek, A., Author
Stark, W., Author
Gaertner, J., Author
Pohl, D., Author
Rostasy, K., Author
Weber, F., Author
Forne, I., Author
Khademi, M., Author
Olsson, T., AuthorBrilot, F., AuthorTantsis, E., AuthorDale, R. C., AuthorWekerle, Hartmut1, Author              Hohlfeld, Reinhard1, Author              Banwell, B., AuthorBar-Or, A., AuthorMeinl, Edgar1, Author              Derfuss, Tobias1, Author               more..
Affiliations:
1Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society, ou_1113547              

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Free keywords: MYELIN OLIGODENDROCYTE GLYCOPROTEIN; PEDIATRIC MULTIPLE-SCLEROSIS; GUILLAIN-BARRE-SYNDROME; DEMYELINATING DISEASES; ANTIMYELIN ANTIBODIES; BASIC-PROTEIN; AUTOANTIBODIES; SPECIFICITY; CHILDREN; ASSOCIATIONClinical Neurology;
 Abstract: Objective: To study the longitudinal dynamics of anti-myelin oligodendrocyte glycoprotein (MOG) autoantibodies in childhood demyelinating diseases. Methods: We addressed the kinetics of anti-MOG immunoglobulins in a prospective study comprising 77 pediatric patients. This was supplemented by a cross-sectional study analyzing 126 pediatric patients with acute demyelination and 62 adult patients with multiple sclerosis (MS). MOG-transfected cells were used for detection of antibodies by flow cytometry. Results: Twenty-five children who were anti-MOG immunoglobulin (Ig) positive at disease onset were followed for up to 5 years. Anti-MOG antibodies rapidly and continuously declined in all 16 monophasic patients with acute disseminated encephalomyelitis and in one patient with clinically isolated syndrome. In contrast, in 6 of 8 patients (75%) eventually diagnosed with childhood MS, the antibodies to MOG persisted with fluctuations showing a second increase during an observation period of up to 5 years. Antibodies to MOG were mainly IgG 1 and their binding was largely blocked by pathogenic anti-MOG antibodies derived from a spontaneous animal model of autoimmune encephalitis. The cross-sectional part of our study elaborated that anti-MOG Ig was present in about 25% of children with acute demyelination, but in none of the pediatric or adult controls. Sera from 4/62 (6%) adult patients with MS had anti-MOG IgG at low levels. Conclusions: The persistence or disappearance of antibodies to MOG may have prognostic relevance for acute childhood demyelination. Neurology (R) 2011;77:580-588

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Language(s): eng - English
 Dates: 2011
 Publication Status: Published in print
 Pages: 9
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Degree: -

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Title: Neurology
Source Genre: Journal
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Publ. Info: Cleveland, Ohio [etc.] : Advanstar Communications [etc.]
Pages: - Volume / Issue: 77 (6) Sequence Number: - Start / End Page: 580 - 588 Identifier: ISSN: 0028-3878
CoNE: https://pure.mpg.de/cone/journals/resource/954925246073