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  Microstructure of frontoparietal connections predicts cortical responsivity and working memory performance

Burzynska, A. Z., Nagel, I. E., Preuschhof, C., Li, S. C., Lindenberger, U., Bäckman, L., et al. (2011). Microstructure of frontoparietal connections predicts cortical responsivity and working memory performance. Cerebral Cortex, 21(10), 2261-2271. doi:10.1093/cercor/bhq293.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0012-298A-4 Version Permalink: https://hdl.handle.net/21.11116/0000-000D-C04A-7
Genre: Journal Article

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Locator:
https://doi.org/10.1093/cercor/bhq293 (Publisher version)
Description:
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OA-Status:
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 Creators:
Burzynska, Agnieszka Z.1, Author
Nagel, I. E.1, 2, Author
Preuschhof, C.2, Author
Li, S. C.1, Author
Lindenberger, Ulman1, Author
Bäckman, L.1, 3, Author
Heekeren, Hauke1, 2, 4, Author           
Affiliations:
1Max Planck Institute for Human Development, Berlin, Germany, ou_persistent22              
2Department of Education and Psychology, FU Berlin, Germany, ou_persistent22              
3Aging Research Center, Karolinska Institute, Stockholm, Sweden, ou_persistent22              
4MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634548              

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Free keywords: DTI; fMRI; Multimodal; n-back; Superior longitudinal fasciculi
 Abstract: We investigated how the microstructure of relevant white matter connections is associated with cortical responsivity and working memory (WM) performance by collecting diffusion tensor imaging and verbal WM functional magnetic resonance imaging data from 29 young adults. We measured cortical responsivity within the frontoparietal WM network as the difference in blood oxygenation level–dependent (BOLD) signal between 3-back and 1-back conditions. Fractional anisotropy served as an index of the integrity of the superior longitudinal fasciculi (SLF), which connect frontal and posterior regions. We found that SLF integrity is associated with better 3-back performance and greater task-related BOLD responsivity. In addition, BOLD responsivity in right premotor cortex reliably mediated the effects of SLF integrity on 3-back performance but did not uniquely predict 3-back performance after controlling for individual differences in SLF integrity. Our results suggest that task-related adjustments of local gray matter processing are conditioned by the properties of anatomical connections between relevant cortical regions. We suggest that the microarchitecture of white matter tracts influences the speed of signal transduction along axons. This in turn may affect signal summation at neural dendrites, action potential firing, and the resulting BOLD signal change and responsivity.

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Language(s): eng - English
 Dates: 2011-02-242011
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1093/cercor/bhq293
PMID: 21350048
 Degree: -

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Project name : -
Grant ID : M.FE.A.BILD0005
Funding program : Innovation Fund
Funding organization : Max Planck Society (MPG)
Project name : -
Grant ID : 01GO0501
Funding program : -
Funding organization : Federal Ministry of Education and Research (BMBF)
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Grant ID : -
Funding program : -
Funding organization : German Research Foundation (DFG)
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Grant ID : -
Funding program : -
Funding organization : German Research Council
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Grant ID : -
Funding program : Alexander von Humboldt Research Award
Funding organization : Alexander-von-Humboldt-Stiftung
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Grant ID : -
Funding program : -
Funding organization : Swedish Brain Power
Project name : -
Grant ID : -
Funding program : -
Funding organization : Swedish Research Council
Project name : The Life Course: Evolutionary and Ontogenetic Dynamics
Grant ID : -
Funding program : LIFE
Funding organization : International Max Planck Research School

Source 1

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Title: Cerebral Cortex
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York, NY : Oxford University Press
Pages: - Volume / Issue: 21 (10) Sequence Number: - Start / End Page: 2261 - 2271 Identifier: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440