English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Focal retrograde amnesia: Voxel-based morphometry findings in a case without MRI lesions

Sehm, B., Frisch, S., Thöne-Otto, A., Horstmann, A., Villringer, A., & Obrig, H. (2011). Focal retrograde amnesia: Voxel-based morphometry findings in a case without MRI lesions. PLoS One, 6(10): e26538. doi:10.1371/journal.pone.0026538.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-2A8C-7 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-C406-F
Genre: Journal Article

Files

show Files
hide Files
:
Sehm_FocalRetrograde.pdf (Publisher version), 143KB
Name:
Sehm_FocalRetrograde.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
2011
Copyright Info:
© 2011 Sehm et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Locators

show

Creators

show
hide
 Creators:
Sehm, Bernhard1, Author              
Frisch, Stefan1, Author              
Thöne-Otto, Angelika1, Author              
Horstmann, Annette1, Author              
Villringer, Arno1, Author              
Obrig, Hellmuth1, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

Content

show
hide
Free keywords: -
 Abstract: Focal retrograde amnesia (FRA) is a rare neurocognitive disorder presenting with an isolated loss of retrograde memory. In the absence of detectable brain lesions, a differentiation of FRA from psychogenic causes is difficult. Here we report a case study of persisting FRA after an epileptic seizure. A thorough neuropsychological assessment confirmed severe retrograde memory deficits while anterograde memory abilities were completely normal. Neurological and psychiatric examination were unremarkable and high-resolution MRI showed no neuroradiologically apparent lesion. However, voxel-based morphometry (VBM)-comparing the MRI to an education-, age-and sex-matched control group (n = 20) disclosed distinct gray matter decreases in left temporopolar cortex and a region between right posterior parahippocampal and lingual cortex. Although the results of VBM-based comparisons between a single case and a healthy control group are generally susceptible to differences unrelated to the specific symptoms of the case, we believe that our data suggest a causal role of the cortical areas detected since the retrograde memory deficit is the preeminent neuropsychological difference between patient and controls. This was paralleled by grey matter differences in central nodes of the retrograde memory network. We therefore suggest that these subtle alterations represent structural correlates of the focal retrograde amnesia in our patient. Beyond the implications for the diagnosis and etiology of FRA, our results advocate the use of VBM in conditions that do not show abnormalities in clinical radiological assessment, but show distinct neuropsychological deficits.

Details

show
hide
Language(s): eng - English
 Dates: 2011-09-282011-10-19
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1371/journal.pone.0026538
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: PLoS One
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 6 (10) Sequence Number: e26538 Start / End Page: - Identifier: ISSN: 1932-6203
CoNE: /journals/resource/1000000000277850