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Abstract:
This thesis deals with the investigation of the biological effectiveness of antiprotons on
V79-WNRE cells (Chinese hamster lung fibroblasts). It describes the development and
operation of an automated, remotely controllable energy changing device to produce
a clinically relevant dose profile. Moreover, for the first time, the use of a " ripple"
filter for further optimization of the profile in an antiproton beam is discussed and
analyzed. A broadening of the measured dose profile of 12 % compared to the ripplefilter-
free beam, is in good agreement with the theoretical predicted 15 %. Due to
the constraints with resprect to the experimental set-up imposed by the Antiproton
Decelerator (AD at CERN) and the resulting long irradiation times, the biological
data set is rather sparse, which complicates the statistical analysis. Because of this, a
detailed discussion on the calculation of the standard deviation of cell survival rates is
performed. Fnrthermore, a new concept is introduced, which unifies the analysis and
includes statistical fluctuat ions.
