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  Age-related differences in white matter microstructure: Region-specific patterns of diffusivity

Burzynska, A., Preuschhof, C., Baeckmann, L., Nyberg, L., Li, S.-C., Lindenberger, U., et al. (2010). Age-related differences in white matter microstructure: Region-specific patterns of diffusivity. NeuroImage, 49(3), 2104-2112. doi:10.1016/j.neuroimage.2009.09.041.

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 Creators:
Burzynska, A.Z.1, Author
Preuschhof, C.1, Author
Baeckmann, L.1, 2, Author
Nyberg, L.3, Author
Li, S.-C.1, Author
Lindenberger, U.1, Author
Heekeren, Hauke R.1, 4, Author              
Affiliations:
1Max Planck Institute for Human Development, Berlin, Germany, ou_persistent22              
2Aging Research Center, Karolinska Institute, Stockholm, Sweden, ou_persistent22              
3Department of Radiation Sciences (Diagnostic Radiology) and Integrative Medical Biology (Physiology Section), Umeå University, Sweden, ou_persistent22              
4MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634548              

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Free keywords: Axial diffusivity; Fractional anisotropy; Mean diffusivity; Radial diffusivity; Tract-based spatial statistics
 Abstract: We collected MRI diffusion tensor imaging data from 80 younger (20–32 years) and 63 older (60–71 years) healthy adults. Tract-based spatial statistics (TBSS) analysis revealed that white matter integrity, as indicated by decreased fractional anisotropy (FA), was disrupted in numerous structures in older compared to younger adults. These regions displayed five distinct region-specific patterns of age-related differences in other diffusivity properties: (1) increases in both radial and mean diffusivity; (2) increases in radial diffusivity; (3) no differences in parameters other than FA; (4) a decrease in axial and an increase in radial diffusivity; and (5) a decrease in axial and mean diffusivity. These patterns suggest different biological underpinnings of age-related decline in FA, such as demyelination, Wallerian degeneration, gliosis, and severe fiber loss, and may represent stages in a cascade of age-related degeneration in white matter microstructure. This first simultaneous description of age-related differences in FA, mean, axial, and radial diffusivity requires histological and functional validation as well as analyses of intermediate age groups and longitudinal samples.

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Language(s): eng - English
 Dates: 2009-08-152009-03-092009-09-212009-09-252010-02-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2009.09.041
 Degree: -

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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 49 (3) Sequence Number: - Start / End Page: 2104 - 2112 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166