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  Differential influence of levodopa on reward-based learning in Parkinson's disease

Graef, S., Biele, G., Krugel, L. K., Marzinzik, F., Wahl, M., Wotka, J., et al. (2010). Differential influence of levodopa on reward-based learning in Parkinson's disease. Frontiers in Human Neuroscience, 4: 169. doi:10.3389/fnhum.2010.00169.

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 Creators:
Graef, Susanne1, 2, Author              
Biele, Guido1, 3, Author
Krugel, Lea K.1, 4, Author
Marzinzik, Frank4, Author
Wahl, Michael4, Author
Wotka, Johann4, Author
Klostermann, Fabian4, Author
Heekeren, Hauke R.1, Author              
Affiliations:
1Max Planck Institute for Human Development, Berlin, Germany, ou_persistent22              
2MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634548              
3Department of Psychology, University of Oslo, Norway, ou_persistent22              
4Department of Neurology, Charité, Campus Benjamin Franklin, Berlin, Germany, ou_persistent22              

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Free keywords: Levodopa; Decision-making; Reinforcement learning; Reversal learning; Overdose hypothesis; PD; Reward contingencies
 Abstract: The mesocorticolimbic dopamine (DA) system linking the dopaminergic midbrain to the prefrontal cortex and subcortical striatum has been shown to be sensitive to reinforcement in animals and humans. Within this system, coexistent segregated striato-frontal circuits have been linked to different functions. In the present study, we tested patients with Parkinson’s disease (PD), a neurodegenerative disorder characterized by dopaminergic cell loss, on two reward-based learning tasks assumed to differentially involve dorsal and ventral striato-frontal circuits. 15 non-depressed and non-demented PD patients on levodopa monotherapy were tested both on and off medication. Levodopa had beneficial effects on the performance on an instrumental learning task with constant stimulus-reward associations, hypothesized to rely on dorsal striato-frontal circuits. In contrast, performance on a reversal learning task with changing reward contingencies, relying on ventral striato-frontal structures, was better in the unmedicated state. These results are in line with the “overdose hypothesis” which assumes detrimental effects of dopaminergic medication on functions relying upon less affected regions in PD. This study demonstrates, in a within-subject design, a double dissociation of dopaminergic medication and performance on two reward-based learning tasks differing in regard to whether reward contingencies are constant or dynamic. There was no evidence for a dose effect of levodopa on reward-based behavior with the patients’ actual levodopa dose being uncorrelated to their performance on the reward-based learning tasks.

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Language(s): eng - English
 Dates: 2010-08-082010-10-14
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.3389/fnhum.2010.00169
 Degree: -

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Title: Frontiers in Human Neuroscience
  Abbreviation : Front Hum Neurosci
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 4 Sequence Number: 169 Start / End Page: - Identifier: ISSN: 1662-5161
CoNE: https://pure.mpg.de/cone/journals/resource/1662-5161