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  Evaluation of disease activity and damage in different subtypes of cutaneous lupus erythematosus using the CLASI

Bein, D., Kuehn, E., Meuth, A., Amler, S., Haust, M., Nyberg, F., et al. (2011). Evaluation of disease activity and damage in different subtypes of cutaneous lupus erythematosus using the CLASI. Journal of the European Academy of Dermatology and Venereology, 25(6), 652-659. doi:10.1111/j.1468-3083.2010.03844.x.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-32E2-D Version Permalink: http://hdl.handle.net/21.11116/0000-0002-007E-1
Genre: Journal Article

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 Creators:
Bein, Dennis1, Author
Kuehn, Esther1, Author              
Meuth, Anne1, Author
Amler, S.2, Author
Haust, Merle3, Author
Nyberg, Filippa4, Author
Sauerland, C.2, Author
Luger, T.A.1, Author
Bonsmann, Giesela1, Author
Kuhn, Annegret1, Author
Affiliations:
1Department of Dermatology, University of Münster, Germany, ou_persistent22              
2Department of Medical Informatics and Biomathematics, University of Münster, Germany, ou_persistent22              
3Department of Dermatology, University of Düsseldorf, Germany, ou_persistent22              
4Department of Dermatology, Akademiska University Hospital, Uppsala, Sweden, ou_persistent22              

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Free keywords: Activity; CLASI; Cutaneous lupus erythematosus; Damage; Score; Severity index
 Abstract: Background  The Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) is a scoring system for patients with cutaneous lupus erythematosus (CLE) to assess disease activity and damage. Objective  The aim of this study was to evaluate whether the CLASI is a useful instrument which reflects the different subtypes of CLE comparably well in each parameter. Methods  A total of 50 patients (42 female, 8 male) with different subtypes of CLE, including acute CLE (ACLE), subacute CLE (SCLE), chronic CLE (CCLE) and LE tumidus (LET), from the Departments of Dermatology, University of Düsseldorf, Germany, and Danderyd Hospital, Stockholm, Sweden, were evaluated using the CLASI at one time point. Results  The total CLASI activity score was significantly lower in patients with LET compared with ACLE (P < 0.05) and CCLE (P < 0.001), and the total CLASI damage score was significantly lower in patients with LET than with ACLE (P < 0.05), SCLE (P < 0.001) and CCLE (P < 0.001). The erythema score and the scale/hypertrophy score were significantly lower in LET than in ACLE (P < 0.05, both) and CCLE (P < 0.05 and P < 0.001, respectively). The dyspigmentation score was lowest in patients with LET, differing significantly from ACLE (P < 0.05), SCLE (P < 0.05) and CCLE (P < 0.001). The scarring/atrophy/panniculitis score was significantly higher in patients with CCLE in contrast to SCLE and LET (P < 0.05 and P < 0.001, respectively). Conclusion  These data characterize the CLASI as an overall useful instrument to analyse disease activity and damage in CLE. However, the CLASI does not give an accurate assessment of all disease subtypes; therefore, a revision of the CLASI with critical analysis of all parameters is recommended.

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Language(s): eng - English
 Dates: 2011-06
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1111/j.1468-3083.2010.03844.x
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Title: Journal of the European Academy of Dermatology and Venereology
  Abbreviation : J Eur Acad Dermatol Venereol
Source Genre: Journal
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Pages: - Volume / Issue: 25 (6) Sequence Number: - Start / End Page: 652 - 659 Identifier: ISSN: 0926-9959
CoNE: /journals/resource/0926-9959