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  An implantable RF solenoid for magnetic resonance microscopy and microspectroscopy

Rivera, D., Cohen, M., Clark, W. G., Chu, A., Nunnally, R., Smith, J., et al. (2012). An implantable RF solenoid for magnetic resonance microscopy and microspectroscopy. IEEE Transactions on Biomedical Engineering, 59(8), 2118-2125. doi:10.1109/TBME.2011.2178239.

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Rivera_2012_Implantable.pdf (Publisher version), 664KB
 
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 Creators:
Rivera, Deborah1, Author              
Cohen, Mark2, Author
Clark, W. G.3, Author
Chu, Allen4, Author
Nunnally, Ray5, Author
Smith, Jolinda5, Author
Mills, Dixie6, Author
Judy, Jack4, 7, Author
Affiliations:
1Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634550              
2Department of Psychiatry, University of California, Los Angeles, CA, USA, ou_persistent22              
3Department of Physics and Astronomy, University of California, Los Angeles, CA, USA, ou_persistent22              
4Department of Electrical Engineering, University of California, Los Angeles, CA, USA, ou_persistent22              
5Robert and Beverly Lewis Center for NeuroImaging, University of Oregon, Eugene, OR, USA, ou_persistent22              
6Harvard Vanguard Medical Associates, Boston, MA, USA, ou_persistent22              
7Microsystems Technology Office, Defense Advanced Research Projects Agency, Washington, DC, USA, ou_persistent22              

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Free keywords: Implantable biomedical devices; Microscopy; Neural microtechnology; Nuclear imaging
 Abstract: Miniature solenoids routinely enhance small volume nuclear magnetic resonance imaging and spectroscopy; however, no such techniques exist for patients. We present an implantable microcoil for diverse clinical applications, with a microliter coil volume. The design is loosely based on implantable depth electrodes, in which a flexible tube serves as the substrate, and a metal stylet is inserted into the tube during implantation. The goal is to provide enhanced signal-to-noise ratio (SNR) of structures that are not easily accessed by surface coils. The first-generation prototype was designed for implantation up to 2 cm, and provided initial proof-of-concept for microscopy. Subsequently, we optimized the design to minimize the influence of lead inductances, and to thereby double the length of the implantable depth (4 cm). The second-generation design represents an estimated SNR improvement of over 30% as compared to the original design when extended to 4 cm. Impedance measurements indicate that the device is stable for up to 24 h in body temperature saline. We evaluated the SNR and MR-related heating of the device at 3T. The implantable microcoil can differentiate fat and water peaks, and resolve submillimeter features.

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Language(s): eng - English
 Dates: 2011-11-012011-12-062012-08
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: PMID: 22156945
DOI: 10.1109/TBME.2011.2178239
PMC: PMC4497577
Other: Epub 2011
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Title: IEEE Transactions on Biomedical Engineering
Source Genre: Journal
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Publ. Info: New York, NY : Institute of Electrical and Electronics Engineers
Pages: - Volume / Issue: 59 (8) Sequence Number: - Start / End Page: 2118 - 2125 Identifier: ISSN: 0018-9294
CoNE: https://pure.mpg.de/cone/journals/resource/991042742034490