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  The basic helix-loop-helix transcription factor family in plants: A genome-wide study of protein structure and functional diversity

Heim, M. A., Jakoby, M., Werber, M., Martin, C., Weisshaar, B., & Bailey, P. C. (2003). The basic helix-loop-helix transcription factor family in plants: A genome-wide study of protein structure and functional diversity. Molecular Biology and Evolution, 20(5), 735-747.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-3CDF-D Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-3CE0-7
Genre: Journal Article

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 Creators:
Heim, M. A.1, Author              
Jakoby, M.2, Author              
Werber, M.2, Author              
Martin, C., Author
Weisshaar, B.2, 3, Author              
Bailey, P. C., Author
Affiliations:
1Dept. of Plant Breeding and Yield Physiology (Francesco Salamini), MPI for Plant Breeding Research, Max Planck Society, ou_1113570              
2ADIS, MPI for Plant Breeding Research, Max Planck Society, ou_1113564              
3Dept. of Biochemistry (Klaus Hahlbrock), MPI for Plant Breeding Research, Max Planck Society, ou_1113566              

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Free keywords: bHLH; Arabidopsis thaliana; transcription control; genomics
 Abstract: Basic helix-loop-helix (bHLH) transcription factors (TFs) belong to a family of transcriptional regulators present in three eukaryotic kingdoms. Many different functions have been identified for these proteins in animals, including the control of cell proliferation and development of specific cell lineages. Their mechanism for controlling gene transcription often involves homodimerization or heterodimerization. In plants, little is known about the bHLH family, but we have determined that there are 133 bHLH genes in Arabidopsis thaliana and have confirmed that at least 113 of them are expressed. The AtbHLH genes constitute one of the largest families of transcription factors in A. thaliana with significantly more members than are found in most animal species and about an equivalent number to those in vertebrates. Comparisons with animal sequences suggest that the majority of plant bHLH genes have evolved from the ancestral group B class of bHLH genes. By studying the AtbHLH genes collectively, twelve subfamilies have been identified. Within each of these main groups, there are conserved amino acid sequence motifs outside the DNA binding domain. Potential gene redundancy among members of smaller subgroups has been analyzed, and the resulting information is presented to provide a simplified visual interpretation of the gene family, identifying related genes that are likely to share similar functions. Based on the current characterization of a limited number of plant bHLH proteins, we predict that this family of TFs has a range of different roles in plant cell and tissue development as well as plant metabolism.

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Language(s): eng - English
 Dates: 2003-05
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 127300
ISI: 000182693700008
 Degree: -

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Title: Molecular Biology and Evolution
  Alternative Title : Mol. Biol. Evol.
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 20 (5) Sequence Number: - Start / End Page: 735 - 747 Identifier: ISSN: 0737-4038