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  Molecular phylogeny and evolution of the plant-specific seven- transmembrane MLO family

Devoto, A., Hartmann, H. A., Piffanelli, P., Elliott, C., Simmons, C., Taramino, G., et al. (2003). Molecular phylogeny and evolution of the plant-specific seven- transmembrane MLO family. Journal of Molecular Evolution, 56(1), 77-88.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-3D0C-0 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-3D0D-E
Genre: Journal Article

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 Creators:
Devoto, A., Author
Hartmann, H. A.1, Author              
Piffanelli, P., Author
Elliott, C., Author
Simmons, C., Author
Taramino, G., Author
Goh, C. S., Author
Cohen, F. E., Author
Emerson, B. C., Author
Schulze-Lefert, P.1, Author              
Panstruga, R.1, Author              
Affiliations:
1Dept. of Plant Microbe Interactions (Paul Schulze-Lefert), MPI for Plant Breeding Research, Max Planck Society, ou_1113572              

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Free keywords: seven-transmembrane protein; coevolution; gene family; exon/exon junctions; Mlo; G-protein coupled receptor
 Abstract: Homologues of barley Mlo encode the only family of seven- transmembrane (TM) proteins in plants. Their topology, subcellular localization, and sequence diversification are reminiscent of those of G-protein coupled receptors (GPCRs) from animals and fungi. We present a computational analysis of MLO family members based on 31 full-size and 3 partial sequences, which originate from several monocot species, the dicot Arabidopsis thaliana, and the moss Ceratodon purpureus. This enabled us to date the origin of the Mlo gene family back at least to the early stages of land plant evolution. The genomic organization of the corresponding genes supports a monophyletic origin of the Mlo gene family. Phylogenetic analysis revealed five clades, of which three contain both monocot and dicot members, while two indicate class-specific diversification. Analysis of the ratio of nonsynonymous-to- synonymous changes in coding sequences provided evidence for functional constraint on the evolution of the DNA sequences and purifying selection, which appears to be reduced in the first extracellular loop of 12 closely related orthologues. The 31 full-size sequences were examined for potential domain-specific intramolecular coevolution. This revealed evidence for concerted evolution of all three cytoplasmic domains with each other and the C-terminal cytoplasmic tail, suggesting interplay of all intracellular domains for MLO function.

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Language(s): eng - English
 Dates: 2003-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: eDoc: 28754
ISI: 000180306500009
 Degree: -

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Title: Journal of Molecular Evolution
  Alternative Title : J. Mol. Evol.
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 56 (1) Sequence Number: - Start / End Page: 77 - 88 Identifier: ISSN: 0022-2844