English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Calmodulin interacts with MLO protein to regulate defence against mildew in barley

Kim, M. C., Panstruga, R., Elliott, C., Mueller, J., Devoto, A., Yoon, H. W., et al. (2002). Calmodulin interacts with MLO protein to regulate defence against mildew in barley. Nature, 416(6879), 447-450.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-3DF5-2 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-3DF6-F
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Kim, M. C., Author
Panstruga, R.1, Author              
Elliott, C., Author
Mueller, J., Author
Devoto, A., Author
Yoon, H. W., Author
Park, H. C., Author
Cho, M. J.1, Author              
Schulze-Lefert, P.1, Author              
Affiliations:
1Dept. of Plant Microbe Interactions (Paul Schulze-Lefert), MPI for Plant Breeding Research, Max Planck Society, ou_1113572              

Content

show
hide
Free keywords: -
 Abstract: In plants, defence against specific isolates of a pathogen can be triggered by the presence of a corresponding race-specific resistance gene(1), whereas resistance of a more broad-spectrum nature can result from recessive, presumably loss-of- regulatory-function, mutations(2). An example of the latter are mlo mutations in barley, which have been successful in agriculture for the control of powdery mildew fungus (Blumeria graminis f. sp. hordei; Bgh)(3). MLO protein resides in the plasma membrane, has seven transmembrane domains, and is the prototype of a sequence-diversified family unique to plants(4,5), reminiscent of the seven-transmembrane receptors in fungi and animals(5). In animals, these are known as G- protein-coupled receptors and exist in three main families, lacking sequence similarity, that are thought to be an example of molecular convergence(6). MLO seems to function independently of heterotrimeric G proteins. We have identified a domain in MLO that mediates a Ca2+-dependent interaction with calmodulin in vitro. Loss of calmodulin binding halves the ability of MLO to negatively regulate defence against powdery mildew in vivo. We propose a sensor role for MLO in the modulation of defence reactions.

Details

show
hide
Language(s): eng - English
 Dates: 2002-03-28
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: eDoc: 28814
ISI: 000174607800051
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Nature
  Alternative Title : Nature
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 416 (6879) Sequence Number: - Start / End Page: 447 - 450 Identifier: ISSN: 0028-0836