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  The RAR1 interactor SGT1, an essential component of R gene- triggered disease resistance

Azevedo, C., Sadanandom, A., Kitagawa, K., Freialdenhoven, A., Shirasu, K., & Schulze-Lefert, P. (2002). The RAR1 interactor SGT1, an essential component of R gene- triggered disease resistance. Science, 295(5562), 2073-2076.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-3DF9-9 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-3DFA-7
Genre: Journal Article

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 Creators:
Azevedo, C., Author
Sadanandom, A., Author
Kitagawa, K., Author
Freialdenhoven, A.1, Author              
Shirasu, K., Author
Schulze-Lefert, P.1, Author              
Affiliations:
1Dept. of Plant Microbe Interactions (Paul Schulze-Lefert), MPI for Plant Breeding Research, Max Planck Society, ou_1113572              

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 Abstract: Plant disease resistance (R) genes trigger innate immune responses upon pathogen attack. RAR1 is an early convergence: point in a signaling pathway engaged by multiple R genes. Here, vie show that RAR1 interacts with plant orthologs of the yeast protein SGT1, an essential regulator in the cell cycle. Silencing the barley gene Sgt1 reveals its role in R gene- triggered, Rar1-dependent disease resistance. SGT1 associates with SKP1 and CUL1, subunits of the SCF (Skp1-Cullin-F-box) ubiquitin ligase complex. Furthermore, the RAR1-SGT1 complex also interacts with two COP9 signalosome components. The interactions among RAR1, SGT1, SCF, and signalosome subunits indicate a link between disease resistance and ubiquitination.

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Language(s): eng - English
 Dates: 2002-03-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: eDoc: 28821
ISI: 000174450500049
 Degree: -

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Title: Science
  Alternative Title : Science
Source Genre: Journal
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Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 295 (5562) Sequence Number: - Start / End Page: 2073 - 2076 Identifier: ISSN: 0036-8075