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  Ectopic B-Type cyclin expression induces mitotic cycles in endoreduplicating Arabidopsis trichomes

Schnittger, A., Schobinger, U., Stierhof, Y.-D., & Huelskamp, M. (2002). Ectopic B-Type cyclin expression induces mitotic cycles in endoreduplicating Arabidopsis trichomes. Current Biology, 12(5), 415-420.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-3DFB-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-3DFC-3
Genre: Journal Article

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Schnittger, A.1, Author              
Schobinger, U., Author
Stierhof, Y.-D., Author
Huelskamp, M., Author
Affiliations:
1Other Publications, MPI for Plant Breeding Research, Max Planck Society, ou_1113577              

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 Abstract: Cell differentiation is frequently accompanied by a switch from a mitotic division cycle to an endoreduplication cycle. In endoreduplicating cells, DNA synthesis continues in the absence of cell divisions, and it is speculated that endoreduplication represents a shortened mitotic division cycle [1, 2]. In animals, it has been shown that cells switching from mitotic to endoreduplication cycles continue to express factors controlling the G1-S transition, whereas the transcription of mitotic factors controlling the G2-M transition is negatively regulated [3, 4]. It is unknown how the mitotic factors are repressed and what the functional significance of their suppression is. To test the function of two mitotic; cyclins in an endoreduplication cycle, we expressed CYCLIN B1;1 and CYCLIN B1;2 [5, 6] in unicellular Arabidopsis trichomes. During wild- type development, trichomes undergo an average of four endoreduplication cycles, leading to a DNA content of approximately 32C [7, 8]. We find that ectopic expression of CYCLIN B1;2, not CYCLIN B1;1, induces mitotic divisions resulting in multicellular trichomes. The CYCLIN B1,2-triggered cell divisions appeared normal with respect to both nuclear division and cytokinesis. We show that CYCLIN B1;2 is misexpressed in the siamese mutant, which also produces multicellular trichomes [9]. Additional overexpression of CYCLIN B1;2 in a siamese mutant background caused a strongly enhanced phenotype.

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Language(s): eng - English
 Dates: 2002-03-05
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: eDoc: 127733
ISI: 000174261700024
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Title: Current Biology
  Alternative Title : Curr. Biol.
Source Genre: Journal
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Pages: - Volume / Issue: 12 (5) Sequence Number: - Start / End Page: 415 - 420 Identifier: ISSN: 0960-9822