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  Modeling brain resonance phenomena using a neural mass model

Spiegler, A., Knösche, T. R., Schwab, K., Haueisen, J., & Atay, F. M. (2011). Modeling brain resonance phenomena using a neural mass model. PLoS Computational Biology, 7(12): e1002298. doi:10.1371/journal.pcbi.1002298.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-5BC8-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-9E7D-1
Genre: Journal Article

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 Creators:
Spiegler, Andreas1, 2, Author              
Knösche, Thomas R.3, Author              
Schwab, Karin4, 5, Author
Haueisen, Jens2, Author
Atay, Fatihcan M.6, Author
Affiliations:
1Methods and Development Unit Cortical Networks and Cognitive Functions, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634557              
2Institute for Biomedical Engineering and Informatics, TU Ilmenau, Germany, ou_persistent22              
3Methods and Development Group MEG and EEG - Cortical Networks and Cognitive Functions, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_2205650              
4Bernstein Group for Computational Neuroscience, Jena, Germany, ou_persistent22              
5Institute of Medical Statistics, Computer Sciences and Documentation, Jena University Hospital, Germany, ou_persistent22              
6Max Planck Institute for Mathematics in the Sciences, Leipzig, Germany, ou_persistent22              

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 Abstract: Stimulation with rhythmic light flicker (photic driving) plays an important role in the diagnosis of schizophrenia, mood disorder, migraine, and epilepsy. In particular, the adjustment of spontaneous brain rhythms to the stimulus frequency (entrainment) is used to assess the functional flexibility of the brain. We aim to gain deeper understanding of the mechanisms underlying this technique and to predict the effects of stimulus frequency and intensity. For this purpose, a modified Jansen and Rit neural mass model (NMM) of a cortical circuit is used. This mean field model has been designed to strike a balance between mathematical simplicity and biological plausibility. We reproduced the entrainment phenomenon observed in EEG during a photic driving experiment. More generally, we demonstrate that such a single area model can already yield very complex dynamics, including chaos, for biologically plausible parameter ranges. We chart the entire parameter space by means of characteristic Lyapunov spectra and Kaplan-Yorke dimension as well as time series and power spectra. Rhythmic and chaotic brain states were found virtually next to each other, such that small parameter changes can give rise to switching from one to another. Strikingly, this characteristic pattern of unpredictability generated by the model was matched to the experimental data with reasonable accuracy. These findings confirm that the NMM is a useful model of brain dynamics during photic driving. In this context, it can be used to study the mechanisms of, for example, perception and epileptic seizure generation. In particular, it enabled us to make predictions regarding the stimulus amplitude in further experiments for improving the entrainment effect.

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Language(s): eng - English
 Dates: 2011-10-252011-12-22
 Publication Status: Published online
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 Rev. Method: Peer
 Identifiers: DOI: 10.1371/journal.pcbi.1002298
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Title: PLoS Computational Biology
Source Genre: Journal
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Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 7 (12) Sequence Number: e1002298 Start / End Page: - Identifier: ISSN: 1553-734X
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000017180_1