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  Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers

Hartz, S. M., Short, S. E., Saccone, N. L., Culverhouse, R., Chen, L., Schwantes-An, T.-H., et al. (2012). Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers. Archives of General Psychiatry, 69, 854-860. doi:10.1001/archgenpsychiatry.2012.124.

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Hartz , Sarah M., Author
Short, Susan E. , Author
Saccone, Nancy L. , Author
Culverhouse, Robert , Author
Chen, LiShiun , Author
Schwantes-An, Tae-Hwi , Author
Coon, Hilary , Author
Han, Younghun , Author
Stephens, Sarah H. , Author
Sun , Juzhong , Author
Chen, Xiangning , Author
Ducci , Francesca , Author
Dueker, Nicole , Author
Franceschini , Nora , Author
Frank, Josef , Author
Geller, Frank , Author
Gubjartsson, Daniel , Author
Hansel, Nadia N., Author
Jiang, Chenhui , Author
Keskitalo-Vuokko, Kaisu , Author
Liu, Zhen , AuthorLyytikainen, Leo-Pekka , AuthorMichel, Martha , AuthorRawal, Rajesh , AuthorRosenberger, Albert , AuthorScheet, Paul , AuthorShaffer, John R. , AuthorTeumer, Alexander , AuthorThompson, John R. , AuthorVink, Jacqueline M. , AuthorVogelzangs, Nicole , AuthorWenzlaff, Angela S., AuthorWheeler, William , AuthorXiao, Xiangjun , AuthorYang, Bao-Zhu , AuthorAggen, Steven H. , AuthorBalmforth, Anthony J. , AuthorBaumeister, Sebastian E. , AuthorBeaty, Terri , AuthorBennett, Siiri, AuthorBergen, Andrew W. , AuthorBoyd, Heather A. , AuthorBroms, Ulla , AuthorCampbell, Harry , AuthorChatterjee, Nilanjan , AuthorChen , Jingchun , AuthorCheng, Yu-Ching , AuthorCichon, Sven , AuthorCouper, David , AuthorCucca, Francesco , AuthorDick, Danielle M. , AuthorForoud, Tatiana , AuthorFurberg , Helena , AuthorGiegling, Ina , AuthorGu, Fangyi , AuthorHall, Alistair S. , AuthorHallfors, Jenni , AuthorHan, Shizhong , AuthorHartmann, Annette M. , AuthorHayward, Caroline , AuthorHeikkila, Kauko , AuthorHewitt, John K. , AuthorHottenga, Jouke Jan , AuthorJensen, Majken K. , AuthorJousilahti , Pekka , AuthorKaakinen, Marika , AuthorKittner , Steven J. , AuthorKonte, Bettina , AuthorKorhonen, Tellervo , AuthorLandi, Maria-Teresa , AuthorLaatikainen , Tiina , AuthorLeppert, Mark , AuthorLevy , Steven M. , AuthorMathias, Rasika A. , AuthorMcNeil, Daniel W. , AuthorMedland, Sarah E. , AuthorMontgomery, Grant W. , AuthorMuley, Thomas , AuthorMurray, Tanda , AuthorNauck, Matthias , AuthorNorth, Kari , AuthorPergadia, Michele , AuthorPolasek , Ozren , AuthorRamos, Erin M. , AuthorRipatti, Samuli , AuthorRisch, Angela , AuthorRuczinski, Ingo , AuthorRudan , Igor , AuthorSalomaa , Veikko , AuthorSchlessinger, David , AuthorStyrkarsdottir, Unnur , AuthorTerracciano, Antonio , AuthorUda, Manuela , AuthorWillemsen, Gonneke , AuthorWu , Xifeng, AuthorAbecasis, Goncalo , AuthorBarnes, Kathleen , AuthorBickeboller, Heike , AuthorBoerwinkle, Eric , AuthorBoomsma, Dorret I. , AuthorCaporaso, Neil , AuthorDuan, Jubao , AuthorEdenberg, Howard J. , AuthorFrancks, Clyde1, 2, Author           Gejman, Pablo V. , AuthorGelernter, Joel , AuthorGrabe, Hans Jorgen , AuthorHops, Hyman , AuthorJarvelin , Marjo-Riitta , AuthorViikari , Jorma , AuthorKahonen , Mika , AuthorKendler, Kenneth S., AuthorLehtimaki , Terho , AuthorLevinson, Douglas F., AuthorMarazita, Mary L. , AuthorMarchini , Jonathan , AuthorMelbye , Mads , AuthorMitchell , Braxton , AuthorMurray, Jeffrey C. , AuthorNothen, Markus M. , AuthorPenninx, Brenda W. , AuthorRaitakari , Olli , AuthorRietschel, Marcella, AuthorRujescu, Dan , AuthorSamani, Nilesh J. , AuthorSanders, Alan R. , AuthorSchwartz, Ann G. , AuthorShete, Sanjay , AuthorShi, Jianxin , AuthorSpitz, Margaret , AuthorStefansson , Kari , AuthorSwan, Gary E. , AuthorThorgeirsson, Thorgeir , AuthorVolzke, Henry , AuthorWei, Qingyi , AuthorWichmann , H.-Erich , AuthorAmos, Christopher I. , AuthorBreslau, Naomi , AuthorCannon, Dale S. , AuthorEhringer, Marissa , AuthorGrucza, Richard , AuthorHatsukami, Dorothy , AuthorHeath, Andrew , AuthorJohnson, Eric O. , AuthorKaprio, Jaakko , AuthorMadden, Pamela , AuthorMartin, Nicholas G. , AuthorStevens, Victoria L. , AuthorStitzel, Jerry A. , AuthorWeiss, Robert B. , AuthorKraft, Peter , AuthorBierut, Laura J. , Author more..
Affiliations:
1Language and Genetics Department, MPI for Psycholinguistics, Max Planck Society, ou_792549              
2Imaging Genomics, MPI for Psycholinguistics, Max Planck Society, Wundtlaan 1, 6525 XD Nijmegen, NL, ou_2579692              

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 Abstract: CONTEXT Recent studies have shown an association between cigarettes per day (CPD) and a nonsynonymous single-nucleotide polymorphism in CHRNA5, rs16969968. OBJECTIVE To determine whether the association between rs16969968 and smoking is modified by age at onset of regular smoking. DATA SOURCES Primary data. STUDY SELECTION Available genetic studies containing measures of CPD and the genotype of rs16969968 or its proxy. DATA EXTRACTION Uniform statistical analysis scripts were run locally. Starting with 94 050 ever-smokers from 43 studies, we extracted the heavy smokers (CPD >20) and light smokers (CPD ≤10) with age-at-onset information, reducing the sample size to 33 348. Each study was stratified into early-onset smokers (age at onset ≤16 years) and late-onset smokers (age at onset >16 years), and a logistic regression of heavy vs light smoking with the rs16969968 genotype was computed for each stratum. Meta-analysis was performed within each age-at-onset stratum. DATA SYNTHESIS Individuals with 1 risk allele at rs16969968 who were early-onset smokers were significantly more likely to be heavy smokers in adulthood (odds ratio [OR] = 1.45; 95% CI, 1.36-1.55; n = 13 843) than were carriers of the risk allele who were late-onset smokers (OR = 1.27; 95% CI, 1.21-1.33, n = 19 505) (P = .01). CONCLUSION These results highlight an increased genetic vulnerability to smoking in early-onset smokers.

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Language(s): eng - English
 Dates: 20112012
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: Archives of General Psychiatry
Source Genre: Journal
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Publ. Info: Chicago : American Medical Association
Pages: - Volume / Issue: 69 Sequence Number: - Start / End Page: 854 - 860 Identifier: ISSN: 0003-990X
CoNE: https://pure.mpg.de/cone/journals/resource/991042742058796