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  A new prospero and microRNA-279 pathway restricts CO2 receptor neuron formation

Hartl, M., Loschek, L., Stephan, D., Siju, K. P., Knappmeyer, C., & Grunwald Kadow, I. C. (2011). A new prospero and microRNA-279 pathway restricts CO2 receptor neuron formation. The Journal of Neuroscience, 31(44), 15660-15673. doi:10.1523/JNEUROSCI.2592-11.2011.

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 Creators:
Hartl, Marion1, Author           
Loschek, Laura1, Author           
Stephan, Daniel1, Author           
Siju, K. P.1, Author           
Knappmeyer, Christiane1, Author           
Grunwald Kadow, Ilona C.1, Author           
Affiliations:
1Max Planck Research Group: Sensory Neurogenetics / Grunwald-Kadow, MPI of Neurobiology, Max Planck Society, ou_1113556              

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Free keywords: SENSE ORGAN LINEAGE; SIBLING CELL FATE; MAXILLARY PALP; DROSOPHILA-ANTENNA; CARBON-DIOXIDE; SELF-RENEWAL; STEM-CELLS; DIFFERENTIATION; GENE; EXPRESSIONNeurosciences;
 Abstract: CO2 sensation represents an interesting example of nervous system and behavioral evolutionary divergence. The underlying molecular mechanisms, however, are not understood. Loss of microRNA-279 in Drosophila melanogaster leads to the formation of a CO2 sensory system partly similar to the one of mosquitoes. Here, we show that a novel allele of the pleiotropic transcription factor Prospero resembles the miR-279 phenotype. We use a combination of genetics and in vitro and in vivo analysis to demonstrate that Pros participates in the regulation of miR-279 expression, and that reexpression of miR-279 rescues the pros CO2 neuron phenotype. We identify common target molecules of miR-279 and Pros in bioinformatics analysis, and show that overexpression of the transcription factors Nerfin-1 and Escargot (Esg) is sufficient to induce formation of CO2 neurons on maxillary palps. Our results suggest that Prospero restricts CO2 neuron formation indirectly via miR-279 and directly by repressing the shared target molecules, Nerfin-1 and Esg, during olfactory system development. Given the important role of Pros in differentiation of the nervous system, we anticipate that miR-mediated signal tuning represents a powerful method for olfactory sensory system diversification during evolution.

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Language(s): eng - English
 Dates: 2011
 Publication Status: Published in print
 Pages: 14
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Degree: -

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Title: The Journal of Neuroscience
  Other : The Journal of Neuroscience: the Official Journal of the Society for Neuroscience
  Abbreviation : J. Neurosci.
Source Genre: Journal
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Publ. Info: Washington, DC : Society of Neuroscience
Pages: - Volume / Issue: 31 (44) Sequence Number: - Start / End Page: 15660 - 15673 Identifier: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187_1