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  k-space and q-space: Combining ultra-high spatial and angular resolution in diffusion imaging using ZOOPPA at 7T

Heidemann, R. M., Anwander, A., Feiweier, T., Knösche, T. R., & Turner, R. (2012). k-space and q-space: Combining ultra-high spatial and angular resolution in diffusion imaging using ZOOPPA at 7T. NeuroImage, 60(2), 967-978. doi:10.1016/j.neuroimage.2011.12.081.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-00CF-F Version Permalink: http://hdl.handle.net/21.11116/0000-0004-5C28-9
Genre: Journal Article

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 Creators:
Heidemann, Robin M.1, Author              
Anwander, Alfred2, Author              
Feiweier, Thorsten3, Author
Knösche, Thomas R.2, Author              
Turner, Robert1, Author              
Affiliations:
1Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634550              
2Methods and Development Unit Cortical Networks and Cognitive Functions, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634557              
3Siemens Sector Healthcare, Erlangen, Germany, ou_persistent22              

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Free keywords: Diffusion MRI; Fiber-tracking; Ultra-high field MRI; Parallel imaging; Zoomed imaging
 Abstract: There is ongoing debate whether using a higher spatial resolution (sampling k-space) or a higher angular resolution (sampling q-space angles) is the better way to improve diffusion MRI (dMRI) based tractography results in living humans. In both cases, the limiting factor is the signal-to-noise ratio (SNR), due to the restricted acquisition time. One possible way to increase the spatial resolution without sacrificing either SNR or angular resolution is to move to a higher magnetic field strength. Nevertheless, dMRI has not been the preferred application for ultra-high field strength (7 T). This is because single-shot echo-planar imaging (EPI) has been the method of choice for human in vivo dMRI. EPI faces several challenges related to the use of a high resolution at high field strength, for example, distortions and image blurring. These problems can easily compromise the expected SNR gain with field strength. In the current study, we introduce an adapted EPI sequence in conjunction with a combination of ZOOmed imaging and Partially Parallel Acquisition (ZOOPPA). We demonstrate that the method can produce high quality diffusion-weighted images with high spatial and angular resolution at 7 T. We provide examples of in vivo human dMRI with isotropic resolutions of 1 mm and 800 μm. These data sets are particularly suitable for resolving complex and subtle fiber architectures, including fiber crossings in the white matter, anisotropy in the cortex and fibers entering the cortex.

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Language(s): eng - English
 Dates: 2011-12-272012-01-112012-04-02
 Publication Status: Published in print
 Pages: -
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 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2011.12.081
PMID: 22245337
Other: Epub 2012
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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 60 (2) Sequence Number: - Start / End Page: 967 - 978 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166