English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  The dynamic structure of filamentous tau.

Bibow, S., Mukrasch, M. D., Chinnathambi, S., Biernat, J., Griesinger, C., Mandelkow, E., et al. (2011). The dynamic structure of filamentous tau. Angewandte Chemie-International Edition, 50(48), 11520-11524. doi:0.1002/anie.20110549.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-13F2-8 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-D0A5-F
Genre: Journal Article

Files

show Files
hide Files
:
1321938.pdf (Publisher version), 2MB
Name:
1321938.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Description:
-

Creators

show
hide
 Creators:
Bibow, S.1, Author              
Mukrasch, M. D., Author
Chinnathambi, S., Author
Biernat, J., Author
Griesinger, C.2, Author              
Mandelkow, E., Author
Zweckstetter, M.1, Author              
Affiliations:
1Research Group of Protein Structure Determination using NMR, MPI for biophysical chemistry, Max Planck Society, ou_578571              
2Department of NMR Based Structural Biology, MPI for biophysical chemistry, Max Planck Society, ou_578567              

Content

show
hide
Free keywords: aggregation;Alzheimer disease;fuzzy coat;paired helical filament;tau protein
 Abstract: Getting inside a fuzzy coat: The dynamic structure of the “fuzzy coat”, N- and C-terminal sections around the core of the tau filament consists of over 200 amino acids, and has been characterized by NMR spectroscopy (see picture, model of the long range interactions). The results indicate how conformation specific antibodies bind to the tau protein (fibers of which are a characteristic symptom of Alzheimer disease).

Details

show
hide
Language(s): eng - English
 Dates: 2011-10-112011
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 0.1002/anie.20110549
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Angewandte Chemie-International Edition
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 50 (48) Sequence Number: - Start / End Page: 11520 - 11524 Identifier: -