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  The dynamic structure of filamentous tau.

Bibow, S., Mukrasch, M. D., Chinnathambi, S., Biernat, J., Griesinger, C., Mandelkow, E., et al. (2011). The dynamic structure of filamentous tau. Angewandte Chemie-International Edition, 50(48), 11520-11524. doi:0.1002/anie.20110549.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-000F-13F2-8 Version Permalink: https://hdl.handle.net/21.11116/0000-000B-14B0-7
Genre: Journal Article

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http://onlinelibrary.wiley.com/doi/10.1002/anie.201105493/pdf (Publisher version)
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 Creators:
Bibow, S.1, Author           
Mukrasch, M. D., Author
Chinnathambi, S., Author
Biernat, J., Author
Griesinger, C.2, Author                 
Mandelkow, E., Author
Zweckstetter, M.1, Author           
Affiliations:
1Research Group of Protein Structure Determination using NMR, MPI for biophysical chemistry, Max Planck Society, ou_578571              
2Department of NMR Based Structural Biology, MPI for biophysical chemistry, Max Planck Society, ou_578567              

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Free keywords: aggregation;Alzheimer disease;fuzzy coat;paired helical filament;tau protein
 Abstract: Getting inside a fuzzy coat: The dynamic structure of the “fuzzy coat”, N- and C-terminal sections around the core of the tau filament consists of over 200 amino acids, and has been characterized by NMR spectroscopy (see picture, model of the long range interactions). The results indicate how conformation specific antibodies bind to the tau protein (fibers of which are a characteristic symptom of Alzheimer disease).

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Language(s): eng - English
 Dates: 2011-10-112011
 Publication Status: Issued
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 Rev. Type: Peer
 Identifiers: DOI: 0.1002/anie.20110549
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Title: Angewandte Chemie-International Edition
Source Genre: Journal
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Pages: - Volume / Issue: 50 (48) Sequence Number: - Start / End Page: 11520 - 11524 Identifier: -