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  Arevir: A Secure Platform for Designing Personalized Antiretroviral Therapies Against HIV

Roomp, K., Beerenwinkel, N., Sing, T., Schülter, E., Büch, J., Sierra-Aragon, S., et al. (2006). Arevir: A Secure Platform for Designing Personalized Antiretroviral Therapies Against HIV. In Data Integration in the Life Sciences (pp. 185-194). Berlin: Springer. doi:10.1007/11799511_16.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-000F-2221-0 Version Permalink: https://hdl.handle.net/21.11116/0000-000F-9847-6
Genre: Conference Report

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Locator:
https://rdcu.be/dOygQ (Publisher version)
Description:
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OA-Status:
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 Creators:
Roomp, Kirsten1, Author           
Beerenwinkel, Niko2, Author
Sing, Tobias1, Author           
Schülter, Eugen2, Author
Büch, Joachim1, Author           
Sierra-Aragon, Saleta2, Author
Däumer, Martin2, Author
Hoffmann, Daniel2, Author
Kaiser, Rolf2, Author
Lengauer, Thomas1, Author           
Selbig, Joachim2, Author
Affiliations:
1Computational Biology and Applied Algorithmics, MPI for Informatics, Max Planck Society, ou_40046              
2External Organizations, ou_persistent22              

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 Abstract: Despite the availability of antiretroviral combination therapies, success in
drug treatment of HIV-infected patients is limited. One reason for therapy
failure is the development of drug-resistant genetic variants. In principle,
the viral genomic sequence provides resistance information and could thus guide
the selection of an optimal drug combination. In practice however, the benefit
of this procedure is impaired by (1) the difficulty in inferring the clinically
relevant information from the genotype of the virus and (2) the restricted
availability of this information. We have developed a secure platform for
collaborative research aimed at optimizing anti-HIV therapies, called Arevir. A
relational database schema was designed and implemented together with a
web-based user interface. Our system provides a basis for monitoring patients,
decision-support, and computational analyses. Thus, it merges clinical,
diagnostic and bioinformatics efforts to exploit genomic and patient therapy
data in clinical practice.

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Language(s): eng - English
 Dates: 20062006
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 314426
Other: Local-ID: C125673F004B2D7B-236FC044A3DD67ADC125729D006059AE-Roomp2006
BibTex Citekey: Roomp2006
DOI: 10.1007/11799511_16
 Degree: -

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Title: Third International Workshop on Data Integration in the Life Sciences
Place of Event: Hinxton, UK
Start-/End Date: 2006-07-22 - 2006-07-22

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Source 1

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Title: Data Integration in the Life Sciences
  Abbreviation : DILS 2006
  Subtitle : Third International Workshop, DILS 2006, Hinxton, UK, July 20-22, 2006, Proceedings
Source Genre: Proceedings
 Creator(s):
Affiliations:
Publ. Info: Berlin : Springer
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 185 - 194 Identifier: ISBN: 978-3-540-36593-8

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Title: Lecture Notes in Bioinformatics
  Abbreviation : LNBI
Source Genre: Series
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Publ. Info: -
Pages: - Volume / Issue: 4075 Sequence Number: - Start / End Page: - Identifier: -