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  Activity-Dependent Clustering of Functional Synaptic Inputs on Developing Hippocampal Dendrites

Kleindienst, T., Winnubst, J., Roth-Alpermann, C., Bonhoeffer, T., & Lohmann, C. (2011). Activity-Dependent Clustering of Functional Synaptic Inputs on Developing Hippocampal Dendrites. NEURON, 72(6), 1012-1024. doi:10.1016/j.neuron.2011.10.015.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-3D43-7 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-3D44-5
Genre: Journal Article

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 Creators:
Kleindienst, Thomas1, Author              
Winnubst, Johan2, Author
Roth-Alpermann, Claudia2, Author
Bonhoeffer, Tobias1, Author              
Lohmann, Christian1, Author              
Affiliations:
1Department: Cellular and Systems Neurobiology / Bonhoeffer, MPI of Neurobiology, Max Planck Society, ou_1113545              
2External Organizations, ou_persistent22              

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Free keywords: NEONATAL-RAT HIPPOCAMPUS; CA1 PYRAMIDAL NEURONS; IN-VIVO; CALCIUM TRANSIENTS; SYNAPSES; CELLS; MECHANISMS; PLASTICITY; DYNAMICS; SYSTEM
 Abstract: During brain development, before sensory systems become functional, neuronal networks spontaneously generate repetitive bursts of neuronal activity, which are typically synchronized across many neurons. Such activity patterns have been described on the level of networks and cells, but the fine-structure of inputs received by an individual neuron during spontaneous network activity has not been studied. Here, we used calcium imaging to record activity at many synapses of hippocampal pyramidal neurons simultaneously to establish the activity patterns in the majority of synapses of an entire cell. Analysis of the spatiotemporal patterns of synaptic activity revealed a fine-scale connectivity rule: neighboring synapses (<16 mu m intersynapse distance) are more likely to be coactive than synapses that are farther away from each other. Blocking spiking activity or NMDA receptor activation revealed that the clustering of synaptic inputs required neuronal activity, demonstrating a role of developmentally expressed spontaneous activity for connecting neurons with subcellular precision.

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Language(s): eng - English
 Dates: 2011
 Publication Status: Published in print
 Pages: 13
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Degree: -

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Title: NEURON
Source Genre: Journal
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Publ. Info: 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA : CELL PRESS
Pages: - Volume / Issue: 72 (6) Sequence Number: - Start / End Page: 1012 - 1024 Identifier: ISSN: 0896-6273