English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Dynamic, adaptive changes in MAO-A binding after alterations in substrate availability: An in vivo [(11)C]-harmine positron emission tomography study

Sacher, J., Rabiner, E. A., Clark, M., Rusjan, P., Soliman, A., Boskovic, R., et al. (2012). Dynamic, adaptive changes in MAO-A binding after alterations in substrate availability: An in vivo [(11)C]-harmine positron emission tomography study. Journal of Cerebral Blood Flow and Metabolism, 32(3), 443-446. doi:10.1038/jcbfm.2011.184.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-43B8-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-5C0D-8
Genre: Journal Article

Files

show Files
hide Files
:
Sacher_2012_Dynamic.pdf (Publisher version), 235KB
 
File Permalink:
-
Name:
Sacher_2012_Dynamic.pdf
Description:
-
Visibility:
Private
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Sacher, Julia1, 2, 3, 4, Author              
Rabiner, Eugenii A.5, Author
Clark, Michael1, 2, Author
Rusjan, Pablo1, Author
Soliman, Alexandra1, 2, Author
Boskovic, Rada1, 5, 6, Author
Kish, Stephen J.1, Author
Wilson, Alan A.1, Author
Houle, Sylvain1, Author
Meyer, Jeffrey H.1, 2, Author
Affiliations:
1Vivian M. Rakoff PET Centre, Centre for Addiction and Mental Health, University of Toronto, ON, Canada, ou_persistent22              
2Mood and Anxiety Disorders Division, Centre for Addiction and Mental Health, University of Toronto, ON, Canada, ou_persistent22              
3Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
4Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
5GlaxoSmithKline, Toronto, ON, Canada, ou_persistent22              
6Clinical Pharmacology and Toxicology Division, The Hospital for Sick Children, University of Toronto, ON, Canada, ou_persistent22              

Content

show
hide
Free keywords: Brain imaging; Depression; Dopamine; Parkinson's disease; Positron emission tomography; 5-HT
 Abstract: Monoamine oxidase A (MAO-A) is an important target in the pathophysiology and therapeutics of major depressive disorder, aggression, and neurodegenerative conditions. We measured the effect of changes in MAO-A substrate on MAO-A binding in regions implicated in affective and neurodegenerative disease with [11C]-harmine positron emission tomography in healthy volunteers. Monoamine oxidase A VT, an index of MAO-A density, was decreased (mean: 14%±9%) following tryptophan depletion in prefrontal cortex (P<0.031), and elevated (mean: 17%±11%) in striatum following carbidopa–levodopa administration (P<0.007). These findings suggest an adaptive role for MAO-A in maintaining monoamine neurotransmitter homeostasis by rapidly compensating fluctuating monoamine levels.

Details

show
hide
Language(s): eng - English
 Dates: 2011-09-012011-05-202011-10-142011-12-212012-03
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/jcbfm.2011.184
PMID: 22186668
PMC: PMC3293124
Other: Epub 2011
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Journal of Cerebral Blood Flow and Metabolism
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York : Lippincott Williams & Wilkins
Pages: - Volume / Issue: 32 (3) Sequence Number: - Start / End Page: 443 - 446 Identifier: ISSN: 0271-678X
CoNE: https://pure.mpg.de/cone/journals/resource/954925503202