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  Somatosensory activation of two fingers can be discriminated with ultrahigh-density diffuse optical tomography

Habermehl, C., Holtze, S., Steinbrink, J., Koch, S. P., Obrig, H., Mehnert, J., et al. (2012). Somatosensory activation of two fingers can be discriminated with ultrahigh-density diffuse optical tomography. NeuroImage, 59(4), 3201-3211. doi:10.1016/j.neuroimage.2011.11.062.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-43C3-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-B01C-7
Genre: Journal Article

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 Creators:
Habermehl, Christina1, Author
Holtze, Susanne2, Author              
Steinbrink, Jens1, 3, Author
Koch, Stefan P.1, Author
Obrig, Hellmuth1, 2, 4, Author              
Mehnert, Jan1, 2, Author              
Schmitz, Christoph H.1, 5, Author
Affiliations:
1Berlin Neuroimaging Center, Charité University Medicine Berlin, Germany, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
3Center for Stroke Research, Charité University Medicine Berlin, Germany, ou_persistent22              
4Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
5NIRx Medizintechnik GmbH, Berlin, Germany, ou_persistent22              

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Free keywords: Near infrared spectroscopy; NIRS; Diffuse optical tomography; DOT; High-density diffuse optical tomography human; Brain; Somatotopy; Vibrotactile stimulation; Comparison NIRS fMRI; Multimodal imaging
 Abstract: Topographic non-invasive near infrared spectroscopy (NIRS) has become a well-established tool for functional brain imaging. Applying up to 100 optodes over the head of a subject, allows achieving a spatial resolution in the centimeter range. This resolution is poor compared to other functional imaging tools. However, recently it was shown that diffuse optical tomography (DOT) as an extension of NIRS based on high-density (HD) probe arrays and supplemented by an advanced image reconstruction procedure allows describing activation patterns with a spatial resolution in the millimeter range. Building on these findings, we hypothesize that HD-DOT may render very focal activations accessible which would be missed by the traditionally used sparse arrays. We examined activation patterns in the primary somatosensory cortex, since its somatotopic organization is very fine-grained. We performed a vibrotactile stimulation study of the first and fifth finger in eight human subjects, using a 900-channel continuous-wave DOT imaging system for achieving a higher resolution than conventional topographic NIRS. To compare the results to a well-established high-resolution imaging technique, the same paradigm was investigated in the same subjects by means of functional magnetic resonance imaging (fMRI). In this work, we tested the advantage of ultrahigh-density probe arrays and show that highly focal activations would be missed by classical next-nearest neighbor NIRS approach, but also by DOT, when using a sparse probe array. Distinct activation patterns for both fingers correlated well with the expected neuroanatomy in five of eight subjects. Additionally we show that activation for different fingers is projected to different tissue depths in the DOT image. Comparison to the fMRI data yielded similar activation foci in seven out of ten finger representations in these five subjects when comparing the lateral localization of DOT and fMRI results.

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Language(s): eng - English
 Dates: 2011-11-012011-08-312011-11-212011-12-012012-02-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2011.11.062
PMID: 22155031
PMC: PMC3288812
arXiv: Epub 2011
 Degree: -

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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 59 (4) Sequence Number: - Start / End Page: 3201 - 3211 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166