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  Quantitative magnetic resonance imaging of cortical multiple sclerosis pathology

Tardif, C., Bedell, B. J., Eskildsen, S. F., Collins, D. L., & Pike, G. B. (2012). Quantitative magnetic resonance imaging of cortical multiple sclerosis pathology. Multiple Sclerosis International, 2012: 742018. doi:10.1155/2012/742018.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-5179-B Version Permalink: http://hdl.handle.net/21.11116/0000-0003-B07C-B
Genre: Journal Article

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 Creators:
Tardif, Christine1, Author              
Bedell, Barry J.2, Author
Eskildsen, Simon F.3, Author
Collins, D. Louis1, Author
Pike, G. Bruce1, Author
Affiliations:
1McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, Quebec, Canada, ou_persistent22              
2Small Animal Imaging Laboratory, Montreal Neurological Institute, Montreal, Quebec, Canada, ou_persistent22              
3Center for Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark, ou_persistent22              

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 Abstract: Although significant improvements have been made regarding the visualization and characterization of cortical multiple sclerosis (MS) lesions using magnetic resonance imaging (MRI), cortical lesions (CL) continue to be under-detected in vivo, and we have a limited understanding of the causes of GM pathology. The objective of this study was to characterize the MRI signature of CLs to help interpret the changes seen in vivo and elucidate the factors limiting their visualization. A quantitative 3D high-resolution (350 μm isotropic) MRI study at 3 Tesla of a fixed post mortem cerebral hemisphere from a patient with MS is presented in combination with matched immunohistochemistry. Type III subpial lesions are characterized by an increase in T1, T2 and M0, and a decrease in MTR in comparison to the normal appearing cortex (NAC). All quantitative MR parameters were associated with cortical GM myelin content, while T1 showed the strongest correlation. The histogram analysis showed extensive overlap between CL and NAC for all MR parameters and myelin content. This is due to the poor contrast in myelin content between CL and NAC in comparison to the variability in myelo-architecture throughout the healthy cortex. This latter comparison is highlighted by the representation of T1 times on cortical surfaces at several laminar depths.

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Language(s): eng - English
 Dates: 2012-08-142012-05-042012-09-052012-11-18
 Publication Status: Published online
 Pages: 13
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1155/2012/742018
PMID: 23213531
PMC: PMC3506905
Other: Epub 2012
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Title: Multiple Sclerosis International
Source Genre: Journal
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Publ. Info: Hindawi Publishing Corporation
Pages: - Volume / Issue: 2012 Sequence Number: 742018 Start / End Page: - Identifier: ISSN: 2090-2654
CoNE: https://pure.mpg.de/cone/journals/resource/2090-2654