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  Psoromic acid derivatives: A new family of small-molecule pre-mRNA splicing inhibitors discovered by a stage-specific high-throughput in vitro splicing assay.

Samatov, T. R., Wolf, A., Odenwälder, P., Bessonov, S., Deraeve, C., Bon, R. S., et al. (2012). Psoromic acid derivatives: A new family of small-molecule pre-mRNA splicing inhibitors discovered by a stage-specific high-throughput in vitro splicing assay. ChemBioChem, 13(5), 640-644. doi:10.1002/cbic.201100790.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-83A1-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-C64C-E
Genre: Journal Article

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1443672.pdf (Publisher version), 2MB
 
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 Creators:
Samatov, T. R.1, Author              
Wolf, A., Author
Odenwälder, P.1, Author              
Bessonov, S.1, Author              
Deraeve, C., Author
Bon, R. S., Author
Waldmann, H., Author
Lührmann, R.1, Author              
Affiliations:
1Department of Cellular Biochemistry, MPI for biophysical chemistry, Max Planck Society, ou_578576              

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 Abstract: Snapshots of spliceosome assembly: A high-throughput in vitro splicing assay has been developed for screening a compound library. The discovered family of pre-mRNA splicing inhibitors comprises lichen secondary metabolites that allow the enrichment of the spliceosomal complexes formed after the spliceosome activation step. Here we identify the structural features important for the compounds' inhibitory activity.

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Language(s): eng - English
 Dates: 2012-02-142012-03-19
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1002/cbic.201100790
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Title: ChemBioChem
Source Genre: Journal
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Pages: - Volume / Issue: 13 (5) Sequence Number: - Start / End Page: 640 - 644 Identifier: -