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  Rcf1 mediates cytochrome oxidase assembly and respirasome formation, revealing heterogeneity of the enzyme complex.

Vukotic, M., Oeljeklaus, S., Wiese, S., Voegtle, F. N., Meisinger, C., Meyer, H. E., et al. (2012). Rcf1 mediates cytochrome oxidase assembly and respirasome formation, revealing heterogeneity of the enzyme complex. Cell Metabolism, 15(3), 336-347. doi:10.1016/j.cmet.2012.01.016.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-849A-E Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-5FCE-0
Genre: Journal Article

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Vukotic, M., Author
Oeljeklaus, S., Author
Wiese, S., Author
Voegtle, F. N., Author
Meisinger, C., Author
Meyer, H. E., Author
Zieseniss, A., Author
Katschienski, D. M., Author
Jans, D. C., Author
Jakobs, S.1, Author              
Warscheid, B., Author
Rehling, P.2, Author              
Deckers, M., Author
Affiliations:
1Research Group of Mitochondrial Structure and Dynamics, MPI for biophysical chemistry, Max Planck Society, ou_578566              
2Max Planck Fellow Peter Rehling, ou_1298545              

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 Abstract: The terminal enzyme of the mitochondrial respiratory chain, cytochrome oxidase, transfers electrons to molecular oxygen, generating water. Within the inner mitochondrial membrane, cytochrome oxidase assembles into supercomplexes, together with other respiratory chain complexes, forming so-called res- pirasomes. Little is known about how these higher oligomeric structures are attained. Here we report on Rcf1 and Rcf2 as cytochrome oxidase subunits in S. cerevisiae . While Rcf2 is specific to yeast, Rcf1 is a conserved subunit with two human ortho- logs, RCF1a and RCF1b. Rcf1 is required for growth in hypoxia and complex assembly of subunits Cox13 and Rcf2, as well as for the oligomerization of a subclass of cytochrome oxidase complexes into respirasomes. Our analyses reveal that the cyto- chrome oxidase of mitochondria displays intrinsic heterogeneity with regard to its subunit composition and that distinct forms of respirasomes can be formed by complex variants.

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Language(s): eng - English
 Dates: 2012-02-162012-03-07
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.cmet.2012.01.016
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Title: Cell Metabolism
Source Genre: Journal
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Pages: - Volume / Issue: 15 (3) Sequence Number: - Start / End Page: 336 - 347 Identifier: -