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  The Catalytic Asymmetric Knoevenagel Condensation

Lee, A., Michrowska, A., Sulzer-Mosse, S., & List, B. (2011). The Catalytic Asymmetric Knoevenagel Condensation. Angewandte Chemie International Edition, 50(7), 1707-1710. doi:10.1002/anie.201006319.

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 Creators:
Lee, Anna1, Author              
Michrowska, Anna1, Author              
Sulzer-Mosse, Sarah1, Author              
List, Benjamin1, Author              
Affiliations:
1Research Department List, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445585              

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Free keywords: α-branched aldehydes; dynamic kinetic resolution; enantioselectivity; Knoevenagel condensation; organocatalysis
 Abstract: 116 years after the discovery of the Knoevenagel condensation, the first catalytic asymmetric variant has been developed. Dynamic kinetic resolution in the reaction of α‐branched aldehydes with malonates in the presence of a newly designed and readily available modified cinchona amine catalyst gives the corresponding alkylidene malonates in high enantioselectivity (see scheme).

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Language(s): eng - English
 Dates: 2010-10-082011-01-202011-02-11
 Publication Status: Published in print
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/anie.201006319
 Degree: -

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Title: Angewandte Chemie International Edition
  Abbreviation : Angew. Chem., Int. Ed.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 50 (7) Sequence Number: - Start / End Page: 1707 - 1710 Identifier: ISSN: 1433-7851
CoNE: https://pure.mpg.de/cone/journals/resource/1433-7851