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  Synthesis, structures and anti-malaria activity of some gold(I) phosphine complexes containing seleno- and thiosemicarbazonato ligands

Molter, A., Rust, J., Lehmann, C. W., Deepa, G., Chiba, P., & Mohr, F. (2011). Synthesis, structures and anti-malaria activity of some gold(I) phosphine complexes containing seleno- and thiosemicarbazonato ligands. Dalton Transactions, 40(38), 9810-9820. doi:10.1039/C1DT10885A.

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 Creators:
Molter, Anja1, Author
Rust, Jörg2, Author              
Lehmann, Christian W.2, Author              
Deepa, Ganesh3, Author
Chiba, Peter3, Author
Mohr, Fabian1, Author
Affiliations:
1Fachbereich C - Anorganische Chemie, Bergische Universität Wuppertal, Wuppertal, Germany, ou_persistent22              
2Service Department Lehmann (EMR), Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445625              
3Institute of Medical Chemistry, Medical University of Vienna, Vienna, Austria, ou_persistent22              

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 Abstract: A series of both mono- and dinuclear gold(I) phosphine complexes containing monoanionic seleno- and thiosemicarbazones as ligands were prepared and fully characterized by spectroscopic methods and, in some cases, by single crystal X-ray diffraction. The in vitro anti-malaria activity of some of these compounds was investigated in chloroquine sensitive strains of Plasmodium falciparum. The IC50 results show that the sulfur containing compounds exhibit activity similar to that of chloroquine, whilst the selenium derivatives display only moderate anti-malaria activity.

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Language(s): eng - English
 Dates: 2011-08-302011-10-14
 Publication Status: Published in print
 Pages: 11
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1039/C1DT10885A
 Degree: -

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Title: Dalton Transactions
  Abbreviation : Dalton Trans.
Source Genre: Journal
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Publ. Info: Cambridge, UK : Royal Society of Chemistry
Pages: - Volume / Issue: 40 (38) Sequence Number: - Start / End Page: 9810 - 9820 Identifier: ISSN: 1477-9226
CoNE: https://pure.mpg.de/cone/journals/resource/954925269323