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  Synthesis of TRIP and Analysis of Phosphate Salt Impurities

Klussmann, M., Ratjen, L., Hoffmann, S., Wakchaure, V., Goddard, R., & List, B. (2010). Synthesis of TRIP and Analysis of Phosphate Salt Impurities. Synlett, (14), 2189-2192. doi:10.1055/s-0030-1258505.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-000F-8D6B-0 Version Permalink: https://hdl.handle.net/21.11116/0000-0008-4839-8
Genre: Journal Article

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 Creators:
Klussmann, Martin1, Author           
Ratjen, Lars2, Author           
Hoffmann, Sebastian2, Author           
Wakchaure, Vijay2, Author           
Goddard, Richard3, Author           
List, Benjamin2, Author           
Affiliations:
1Research Group Klußmann, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445608              
2Research Department List, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445585              
3Service Department Lehmann (EMR), Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445625              

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Free keywords: asymmetric catalysis; phosphates; imine hydrogenation; Brønsted acids; organocatalysis
 Abstract: The chiral phosphoric acid TRIP, a useful Brønsted acid catalyst, easily becomes contaminated with metal impurities in the form of phosphate salts during synthesis. This significantly reduces the content of free acid in the product which can hamper the catalytic activity. Methods to easily judge whether TRIP contains mainly the free acid or phosphate salts are presented, using ¹H NMR spectroscopy or a simple pH test. An improved synthetic protocol for TRIP was established that reliably produces the free acid.

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Language(s): eng - English
 Dates: 2010-09-01
 Publication Status: Issued
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1055/s-0030-1258505
 Degree: -

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Title: Synlett
  Abbreviation : Synlett
Source Genre: Journal
 Creator(s):
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Publ. Info: Stuttgart : Georg Thieme Verlag
Pages: - Volume / Issue: (14) Sequence Number: - Start / End Page: 2189 - 2192 Identifier: ISSN: 0936-5214
CoNE: https://pure.mpg.de/cone/journals/resource/954925570856