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  Studies Enabling a Faster Directed Evolution. Evolving Stereoconvergent Epoxide Hydrolases

Kahakeaw, D. (2008). Studies Enabling a Faster Directed Evolution. Evolving Stereoconvergent Epoxide Hydrolases. PhD Thesis, Ruhr-Universität Bochum, Bochum.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-000F-8FCD-4 Version Permalink: https://hdl.handle.net/21.11116/0000-000D-81E4-F
Genre: Thesis

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 Creators:
Kahakeaw, Daniel1, Author           
Affiliations:
1Research Department Reetz, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445588              

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 Abstract: Within this thesis, methods to address the “numbers problem” in directed
evolution were developed. The investigation centered upon the development of a
robust and reliable platform for the laboratory evolution of epoxide hydrolases.
Through the experimental and statistical evaluation of what is called the “reduced
CASTing” strategy, highly stereoconvergent epoxide hydrolase variants which show
promising properties for synthetic-organic applications were evolved.

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Language(s): eng - English
 Dates: 2008-02-292008-02-29
 Publication Status: Issued
 Pages: 196
 Publishing info: Bochum : Ruhr-Universität Bochum
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 410187
 Degree: PhD

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