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  Catalytic Asymmetric Michael Reactions of Acetaldehyde

García‐García, P., Ladépêche, A., Halder, R., & List, B. (2008). Catalytic Asymmetric Michael Reactions of Acetaldehyde. Angewandte Chemie International Edition, 47(25), 4719-4721. doi:10.1002/anie.200800847.

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 Creators:
García‐García, Patricia1, Author              
Ladépêche, Arnaud1, Author              
Halder, Rajkumar1, Author              
List, Benjamin1, Author              
Affiliations:
1Research Department List, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445585              

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Free keywords: asymmetric catalysis; Michael addition; nitroolefins; organocatalysis; synthetic methods
 Abstract: Acetaldehyde, now a big contender: A silyl prolinol derivative was found to catalyze the first Michael addition of acetaldehyde with both aromatic and aliphatic nitroolefins in excellent enantioselectivities (see scheme, TMS=trimethylsilyl). The utility of the reaction is illustrated in the synthesis of three current pharmaceuticals and in the synthesis of an enantiopure 3‐monosubstituted pyrrolidine.

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Language(s): eng - English
 Dates: 2008-02-202008-06-032008-06-09
 Publication Status: Published in print
 Pages: 3
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/anie.200800847
 Degree: -

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Title: Angewandte Chemie International Edition
  Abbreviation : Angew. Chem., Int. Ed.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 47 (25) Sequence Number: - Start / End Page: 4719 - 4721 Identifier: ISSN: 1433-7851
CoNE: https://pure.mpg.de/cone/journals/resource/1433-7851