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  Controlling the Selectivity and Stability of Proteins by New Strategies in Directed Evolution: The Case of Organocatalytic Enzymes

Reetz, M. T. (2008). Controlling the Selectivity and Stability of Proteins by New Strategies in Directed Evolution: The Case of Organocatalytic Enzymes. In M. T. Reetz, B. List, S. Jaroch, & H. Weinmann (Eds.), Organocatalysis. Ernst Schering Foundation Symposium Proceedings, Vol. 2007/2 (pp. 321-340). Berlin Heidelberg: Springer-Verlag. doi:10.1007/2789_2007_068.

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 Urheber:
Reetz, Manfred T.1, Autor           
Affiliations:
1Research Department Reetz, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445588              

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 Zusammenfassung: The directed evolution of functional enzymes as catalysts in organic reactions has emerged as a powerful method of protein engineering. This includes the directed evolution of enantioselective enzymes as pioneered by the author. In recent years the challenges in this new area of asymmetric catalysis has shifted to solving the problem of probing protein sequence space more efficiently than before. Iterative saturation mutagenesis (ISM) is one way of addressing this crucial question. This chapter reviews the concept of ISM and its application in controlling the enantioselectivity and thermostability of enzymes, specifically those that have an organocatalytic mechanism. Illustrative examples include the directed evolution of lipases, Baeyer-Villigerases and epoxide hydrolases.

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Sprache(n): eng - English
 Datum: 2007-12-182008
 Publikationsstatus: Erschienen
 Seiten: 20
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1007/2789_2007_068
 Art des Abschluß: -

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Titel: Organocatalysis. Ernst Schering Foundation Symposium Proceedings, Vol. 2007/2
Genre der Quelle: Reihe
 Urheber:
Reetz, Manfred T.1, Herausgeber           
List, Benjamin2, Herausgeber           
Jaroch, Stefan3, Herausgeber
Weinmann, Hilmar3, Herausgeber
Affiliations:
1 Research Department Reetz, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445588            
2 Research Department List, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445585            
3 Bayer Schering Pharma AG, 13342 Berlin, Germany, ou_persistent22            
Ort, Verlag, Ausgabe: Berlin Heidelberg : Springer-Verlag
Seiten: - Band / Heft: 2007/2 Artikelnummer: - Start- / Endseite: 321 - 340 Identifikator: ISBN: 9783540734949