English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Practical Proline-catalyzed asymmetric Mannich reaction of aldehydes with N-Boc-imines

Yang, J. W., Stadler, M., & List, B. (2007). Practical Proline-catalyzed asymmetric Mannich reaction of aldehydes with N-Boc-imines. Nature Protocols, 2(8), 1937-1942. doi:10.1038/nprot.2007.272.

Item is

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Yang, Jung Woon1, Author           
Stadler, Michael1, Author           
List, Benjamin1, Author           
Affiliations:
1Research Department List, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445585              

Content

show
hide
Free keywords: -
 Abstract: This protocol describes a procedure for the synthesis of α, β-branched-b-amino aldehydes via Proline-catalyzed asymmetric Mannich reaction of aldehydes with N-tert–butoxycarbonyl-imines. The crystalline β-amino aldehydes are formed in good yields and extremely high levels of diastereo- and enantioselectivities without the need for chromatographic purification and are readily oxidized to the corresponding β-amino acids. The protocol can be completed in approximately 14 h on small scales or up to 30 h on larger scales.

Details

show
hide
Language(s): eng - English
 Dates: 2007-08-02
 Publication Status: Published in print
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/nprot.2007.272
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Nature Protocols
  Abbreviation : Nat. Protoc.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 2 (8) Sequence Number: - Start / End Page: 1937 - 1942 Identifier: ISSN: 1750-2799
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000223800_1