Highly Enantioselective Aza‐Baylis–Hillman Reaction in a Chiral Reaction Medium

Gausepohl, Rolf; Buskens, Pascal; Kleinen, Jochen; Bruckmann, Angelika; Lehmann, Christian W.; Klankermayer, Jürgen; Leitner, Walter

doi:10.1002/anie.200600327

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Highly Enantioselective Aza‐Baylis–Hillman Reaction in a Chiral Reaction Medium

Gausepohl, R., Buskens, P., Kleinen, J., Bruckmann, A., Lehmann, C. W., Klankermayer, J., et al. (2006). Highly Enantioselective Aza‐Baylis–Hillman Reaction in a Chiral Reaction Medium. Angewandte Chemie International Edition, 45(22), 3689-3692. doi:10.1002/anie.200600327.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-000F-9323-C Version Permalink: https://hdl.handle.net/21.11116/0000-0007-197A-5

Genre: Journal Article

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Creators:
Gausepohl, Rolf¹, Author
Buskens, Pascal¹, Author
Kleinen, Jochen¹, Author
Bruckmann, Angelika¹, Author
Lehmann, Christian W.², Author
Klankermayer, Jürgen¹, Author
Leitner, Walter^{1, 3}, Author

Affiliations:
1Institut für Technische und Makromolekulare Chemie, Rheinisch‐Westfälische Technische Hochschule Aachen, Worringerweg 1, 52074 Aachen, Germany, ou_persistent22
2Service Department Lehmann (EMR), Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445625
3Service Department Leitner (Technical Labs), Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445626

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Free keywords: asymmetric synthesis; C-C coupling; chiral solvents; ionic liquids; organocatalysis

Abstract: Let's twist again! The first highly enantioselective asymmetric reaction in which a chiral reaction medium is the sole source of chirality is presented. The aza‐Baylis–Hillman reaction in an ionic liquid with a chiral anion, whose design is based on mechanistic insights, gave products with up to 84 % ee.

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Language(s): eng - English

Dates: Published Online: 2006-05-18Date issued: 2006-05-26

Publication Status: Issued

Pages: 4

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Table of Contents: -

Rev. Type: Peer

Identifiers: DOI: 10.1002/anie.200600327

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Title: Angewandte Chemie International Edition

Abbreviation : Angew. Chem., Int. Ed.

Source Genre: Journal

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Publ. Info: Weinheim : Wiley-VCH

Pages: - Volume / Issue: 45 (22) Sequence Number: - Start / End Page: 3689 - 3692 Identifier: ISSN: 1433-7851
CoNE: https://pure.mpg.de/cone/journals/resource/1433-7851