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  Directed Evolution of Cyclohexanone Monooxygenases: Enantioselective Biocatalysts for the Oxidation of Prochiral Thioethers

Reetz, M. T., Daligault, F., Brunner, B., Hinrichs, H., & Deege, A. (2004). Directed Evolution of Cyclohexanone Monooxygenases: Enantioselective Biocatalysts for the Oxidation of Prochiral Thioethers. Angewandte Chemie International Edition, 43(31), 4078-4081. doi:10.1002/anie.200460311.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-000F-96E9-7 Version Permalink: https://hdl.handle.net/21.11116/0000-0008-90E0-7
Genre: Journal Article

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 Creators:
Reetz, Manfred T.1, Author           
Daligault, Franck1, Author           
Brunner, Birgit1, Author           
Hinrichs, Heike2, Author           
Deege, Alfred2, Author           
Affiliations:
1Research Department Reetz, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445588              
2Service Department Schulze (GC, HPLC), Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445630              

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Free keywords: asymmetric catalysis; directed evolution; enzyme catalysis; protein engineering; sulfoxides
 Abstract: Mutational changes in cyclohexanone monooxygenases (CHMOs), for example the introduction of serine at position 432, lead to surprisingly versatile enantioselective biocatalysts that perform particularly well in the air-mediated partial oxidation of prochiral thioethers (see scheme).

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Language(s): eng - English
 Dates: 2004-08-022004-08-06
 Publication Status: Issued
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/anie.200460311
 Degree: -

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Title: Angewandte Chemie International Edition
  Abbreviation : Angew. Chem., Int. Ed.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 43 (31) Sequence Number: - Start / End Page: 4078 - 4081 Identifier: ISSN: 1433-7851
CoNE: https://pure.mpg.de/cone/journals/resource/1433-7851