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Free keywords:
asymmetric catalysis; directed evolution; enzyme catalysis; protein engineering; sulfoxides
Abstract:
Mutational changes in cyclohexanone monooxygenases (CHMOs), for example the introduction of serine at position 432, lead to surprisingly versatile enantioselective biocatalysts that perform particularly well in the air-mediated partial oxidation of prochiral thioethers (see scheme).