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Free keywords:
asymmetric synthesis; chiral auxiliaries; heterogeneous catalysis; hydrogenation; piperidines
Abstract:
Up to four stereocenters can be created efficiently in a single step by the asymmetric hydrogenation of oxazolidinone‐substituted pyridines (see scheme). Furthermore, selective chirality transfer and nondestructive cleavage of the chiral auxiliary occur under the same reaction conditions, making an additional cleavage step unnecessary.
