The Core Structures of Roseophilin and the Prodigiosin Alkaloids Define a New 
Class of Protein Tyrosine Phosphatase Inhibitors

Fürstner, Alois; Reinecke, Kerstin; Prinz, Heino; Waldmann, Herbert

doi:10.1002/cbic.200400135

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The Core Structures of Roseophilin and the Prodigiosin Alkaloids Define a New Class of Protein Tyrosine Phosphatase Inhibitors

Fürstner, A., Reinecke, K., Prinz, H., & Waldmann, H. (2004). The Core Structures of Roseophilin and the Prodigiosin Alkaloids Define a New Class of Protein Tyrosine Phosphatase Inhibitors. ChemBioChem: A European Journal of Chemical Biology, 5(11), 1575-1579. doi:10.1002/cbic.200400135.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-000F-975B-1 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0028-1446-F

Genre: Journal Article

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Creators:
Fürstner, Alois¹, Author
Reinecke, Kerstin², Author
Prinz, Heino², Author
Waldmann, Herbert^{2, 3}, Author

Affiliations:
1Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445584
2Max-Planck-Institut für Molekulare Physiologie, 44227 Dortmund, Germany, ou_persistent22
3Universität Dortmund, Organische Chemie, 44227 Dortmund, German, ou_persistent22

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Free keywords: alkaloids; biological activity; enzymes; inhibitors; phosphatases; prodigiosin

Abstract: A common core. Protein phosphatases, such as the dual-specificity phosphatase VHR and the tyrosine phosphatase PTP1B, are key regulators of innumerable cellular processes, and new classes of phosphatase inhibitors are in demand. The azafulvene-containing core structures of the roseophilin and prodigiosin alkaloids define such a new class.

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Language(s): eng - English

Dates: Submitted: 2004-05-03Published Online: 2004-10-29Date issued: 2004-11-05

Publication Status: Issued

Pages: 5

Publishing info: -

Table of Contents: -

Rev. Type: Peer

Identifiers: eDoc: 219439
DOI: 10.1002/cbic.200400135
ISI: 000225116400014

Degree: -

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Title: ChemBioChem: A European Journal of Chemical Biology

Other : ChemBioChem

Source Genre: Journal

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Publ. Info: Weinheim, Germany : Wiley-VCH

Pages: - Volume / Issue: 5 (11) Sequence Number: - Start / End Page: 1575 - 1579 Identifier: ISSN: 1439-4227
CoNE: https://pure.mpg.de/cone/journals/resource/110978984568897_1