English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Palladium-catalyzed synthesis of aryl ketones from boronic acids and carboxylic acids activated in situ by pivalic anhydride

Gooßen, L. J., & Ghosh, K. (2002). Palladium-catalyzed synthesis of aryl ketones from boronic acids and carboxylic acids activated in situ by pivalic anhydride. European Journal of Organic Chemistry, (19), 3254-3267. doi:10.1002/1099-0690(200210)2002:19<3254:AID-EJOC3254>3.0.CO;2-6.

Item is

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Gooßen, L. J.1, Author              
Ghosh, K.2, Author              
Affiliations:
1Research Group Goossen, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445603              
2Research Department Reetz, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445588              

Content

show
hide
Free keywords: aryl ketones; boronic acids; carboxylic acids; catalysis; palladium
 Abstract: A new palladium-catalyzed cross-coupling reaction between arylboronic acids and mixed anhydrides, generated in situ from carboxylic acids and pivalic anhydride, is presented. Optimization of the new catalyst and the reaction conditions led to the development of a convenient one-pot ketone synthesis directly from carboxylic and boronic acids in the presence of different (phosphane)palladium complexes in wet THF at 60 degreesC. Systematic studies were performed to elucidate the reaction mechanism of this transformation. The scope and the limitations of the new process are demonstrated by the synthesis of 33 functionalized ketones. ((C) Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002).

Details

show
hide
Language(s): eng - English
 Dates: 2002-10
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: European Journal of Organic Chemistry
  Alternative Title : Eur. J. Org. Chem.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: (19) Sequence Number: - Start / End Page: 3254 - 3267 Identifier: ISSN: 1434-193X