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  A practical NMR-based high-throughput assay for screening enantioselective catalysts and biocatalysts

Reetz, M. T., Eipper, A., Tielmann, P., & Mynott, R. (2002). A practical NMR-based high-throughput assay for screening enantioselective catalysts and biocatalysts. Advanced Synthesis & Catalysis, 344(9), 1008-1016. doi:10.1002/1615-4169(200210)344:9<1008:AID-ADSC1008>3.0.CO;2-T.

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 Creators:
Reetz, M. T.1, Author           
Eipper, A.1, Author           
Tielmann, P.1, Author           
Mynott, R.2, Author           
Affiliations:
1Research Department Reetz, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445588              
2Service Department Mynott (NMR), Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445627              

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Free keywords: asymmetric catalysis; combinatorial catalysis; directed evolution; enzyme screening; NMR spectroscopy
 Abstract: Two NMR-based approaches for high-throughput screening of enantioselective catalysts and biocatalysts are described. One version makes use of pseudo-enantiomers or pseudo-meso- compounds based on C-13-labeling. A throughput of at least 1400 ee determinations per day is possible by using an appropriate flow-through cell and an autosampler. The other approach is based on traditional diastereomer formation using a chiral reagent or complexing agent. The ee values are accurate to within +/-2% and +/-5% of the true values.

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Language(s): eng - English
 Dates: 2002-10
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: Advanced Synthesis & Catalysis
  Alternative Title : Adv. Synth. Catal.
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 344 (9) Sequence Number: - Start / End Page: 1008 - 1016 Identifier: ISSN: 1615-4150