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  Drug release from biodegradable silica fibers

Czuryszkiewicz, T., Ahvenlammi, J., Kortesuo, P., Ahola, M., Kleitz, F., Jokinen, M., et al. (2002). Drug release from biodegradable silica fibers. Journal of Non-Crystalline Solids, 306(1), 1-10. doi:10.1016/S0022-3093(02)01060-8.

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Czuryszkiewicz, T.1, Author
Ahvenlammi, J.1, Author
Kortesuo, P.1, Author
Ahola, M.1, Author
Kleitz, F.2, Author              
Jokinen, M.1, Author
Linden, M.2, Author              
Rosenholm, J. B.1, Author
Affiliations:
1Abo Akad Univ, Dept Phys Chem, Porthansgatan 3-5, FIN-20500; Turku, Finland; Tampere Univ Technol, Inst Fiber Text & Clothing Sci, FIN-33101 Tampere, Finland; Orion Corp, ORION PHARMA, FIN-20101 Turku, Finland; Univ Turku, Inst Dent, FIN-20520 Turku, Finland;, ou_persistent22              
2Research Department Schüth, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445589              

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 Abstract: Sol-gel derived biodegradable SiO2 gel fibers have been prepared and characterized by Raman spectroscopy, SEM, Si-29 MAS NMR and TG=MS, respectively. An active component, dexmedetomidine hydrochloride, was incorporated in situ into the fiber structure, by adding it to the sol used for fiber spinning. The subsequent release of the active component was studied in vitro and shown to be determined by differences in the fiber structure, for which clear but indirect evidence was obtained from the different characterization methods used. (C) 2002 Published by Elsevier Science B.V.

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Language(s): eng - English
 Dates: 2002-07-02
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 20050
DOI: 10.1016/S0022-3093(02)01060-8
ISI: 000176263600001
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Title: Journal of Non-Crystalline Solids
  Alternative Title : J. Non-Cryst. Solids
Source Genre: Journal
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Pages: - Volume / Issue: 306 (1) Sequence Number: - Start / End Page: 1 - 10 Identifier: ISSN: 0022-3093